Hayesville business loop U.S. Route 64 Business (
US 64 Bus) was established in 1971 when mainline US 64 was placed on new bypass south of Hayesville. The business routes follows the old alignment through the downtown area, via Hwy 64 Business, Hiwassee Street and Main Street. ;Major intersections
Franklin–Hendersonville truck route U.S. Route 64 Truck (
US 64 Truck) follows
US 23 from Franklin to
Dillsboro, then east following
US 74 to Hendersonville, for a total of . Signage is not primary, US 64 Truck signs are typically located on the side of major junction changes indicating direction of route. Tractor-trailer trucks are prohibited to use mainline US 64 between Franklin and
Brevard.
Brevard business loop U.S. Route 64 Business (
US 64 Bus.) was established in 1960 as a renumbering of US 64A in downtown Brevard, via Caldwell Street. The business loop appears only in
NCDOT and
AASHTO logs and maps; its actually utilized as westbound
US 64 and southbound
US 276 (between Main Street and Broad Street). In 2006, NCDOT submitted a request to officially make US 64E and US 64W through downtown Brevard, but was denied in the AASHTO Fall Meeting.
Morganton business loop U.S. Route 64 Business (
US 64 Bus) was established in 1960, which followed the old mainline US 64 routing through downtown Morganton before 1956, via Burkemont Avenue, Union Street and Meeting Street. Between 1969 and 1972, US 64 Bus was split into one-way alignments, eastbound continued on Meeting Street while westbound moved onto Union Street. In 1992, a few years after US 64 was rerouted through
Lenoir, US 64 Bus was removed east of Green Street along Meeting and Union Streets to Fleming Drive. Eastbound went north on Green Street to Avery Avenue and westbound went south from Sterling Street to Union Street. Continuing along Avery Avenue and Lenoir Road, it reconnects with mainline US 64, via Sanford Drive. This new alignment adds a short overlap with
NC 181 and a long overlap with
NC 18; its older section west of Green Street continued to share a short overlap with
US 70 Bus. ;Major intersectiion
Asheboro business loop U.S. Route 64 Business (
US 64 Bus) was established in 2020 when mainline US 64 was placed on a new freeway bypass south of Asheboro. The business route continues along the former mainline alignment through the city limits. ;Major intersections
Pittsboro business loop U.S. Route 64 Business (
US 64 Bus) was established in 2005 when mainline US 64 was placed on new freeway bypass north of Pittsboro. The business route continues along the former mainline alignment through the downtown area, via East and West Streets. At center is the county courthouse, surrounded by a roundabout. ;Major intersections
Raleigh–Zebulon business loop U.S. Route 64 Business (
US 64 Bus) was established in 1960 when mainline US 64 was placed on new bypass route north of
Wendell, through
Lizard Lick; the business route travels through downtown Wendell along Wendell boulevard, connecting with
NC 231 (Selma Road). In 2006, US 64/US 264 was placed on new freeway bypass south of
Knightdale; its old alignment becoming another extension of US 64 business, via New Bern Avenue / Knightdale Boulevard and a hidden concurrency along the
Cliff Benson Beltline. ;Major intersections
Spring Hope alternate route U.S. Route 64 Alternate (
US 64 Alt) was established in 1979, replacing the old mainline US 64 through the town of Spring Hope. ;Major intersections
Nashville business loop U.S. Route 64 Business (
US 64 Bus) was established in 1963 when mainline US 64 was placed on new freeway bypass route north of Nashville. The business route follows the old alignment through the downtown area via Western Avenue, Barnes Street, Washington Street, and Eastern Avenue. ;Major intersections
Rocky Mount business loop U.S. Route 64 Business (
US 64 Bus.) was established in 1982, it replaced the old mainline US 64 through downtown Rocky Mount, via Sunset Avenue, Thomas Avenue, and Raleigh Street.
Rocky Mount–Tarboro alternate route U.S. Route 64 Alternate (
US 64 Alt) was established in 1987, replacing the old mainline US 64 between the cities Rocky Mount and Tarboro. ;Major intersections {{NCint {{jctbridge {{NCint ==Former==