A featherweight bout between
Edson Barboza and
Giga Chikadze headlined the event.
The Return of The Ultimate Fighter: Team Volkanovski vs. Team Ortega season finale took place at this event, featuring the tournament finals of both the middleweight and bantamweight divisions. Tresean Gore pulled out of the middleweight final against
Bryan Battle due to a meniscus injury and was replaced by Gilbert Urbina. A light heavyweight bout between
Dustin Jacoby and Askar Mozharov was scheduled for the event. However, Mazharov was removed from the event due to undisclosed reason and was replaced by
Darren Stewart. A welterweight bout between former interim
UFC Lightweight Championship challenger
Kevin Lee and
Sean Brady was rescheduled for the event. The pairing was initially scheduled to take meet at
UFC 264, but Lee withdrew due to an injury and the bout was scrapped. Subsequently, the bout was yet again cancelled after Brady withdrew due to a foot infection. Lee faced
Daniel Rodriguez instead. A flyweight bout between former
UFC Flyweight Championship challenger
Alex Perez and
Matt Schnell was rescheduled for the event. They were originally expected to meet at
UFC 262, before Perez was forced to pull out due to undisclosed reasons. The pairing was eventually shifted to
UFC Fight Night: Brunson vs. Till due to undisclosed reasons. A women's bantamweight bout featuring
Joselyne Edwards and
Zarah Fairn Dos Santos was expected to take place at this event. However, the contest was cancelled in late July as Edwards was removed from the event in favor of another bout against
Jessica-Rose Clark at
UFC Fight Night 196 in October.
Kevin Croom was expected to face Marcelo Rojo in a featherweight bout at the event. However, Croom was removed from the card in mid-August for undisclosed reasons. In turn, Rojo was rescheduled to face
Jonathan Martinez the following week at
UFC Fight Night: Brunson vs. Till.
Antônio Braga Neto and
Abdul Razak Alhassan were expected to meet in a middleweight bout a week earlier at
UFC on ESPN: Cannonier vs. Gastelum. They were eventually rescheduled for this event. However, Neto was pulled from the event on August 21 due to undisclosed reasons and the bout was scrapped. A middleweight bout between
Alessio Di Chirico and Aliaskhab Khizriev was also expected to take place at the event. However, the week before the event, Khizriev withdrew due to an undisclosed injury. Di Chirico was then scheduled to face Alhassan instead. They previously met at
UFC 215, with Vieira winning via a second round arm-triangle choke. However, McMann announced in mid August that a "reinjury" forced her out of the bout. A women's flyweight between
Tracy Cortez and
JJ Aldrich was scheduled for the event. However, Cortez was pulled from the fight due to injury. She was replaced by promotional newcomer
Vanessa Demopoulos. A bantamweight bout between
Mario Bautista and
Guido Cannetti was expected to take place at the event. However, Bautista
tested positive for COVID-19 and was pulled from the card. At the weigh-ins, Martinez weighed in at 140 pounds, four pounds over the bantamweight non-title fight limit. The bout proceeded at a catchweight and he forfeited 30% of his purse to Cannetti. ==Results==