While never officially announced by the organization, the promotion initially wanted to contest the event in
London. It would have marked the promotion's first event in the
United Kingdom since
UFC Fight Night: Till vs. Masvidal in March 2019, as well as the first country other than the
United Arab Emirates to host an international event after the pandemic effects began on mixed martial arts. However, negotiations with the British officials fizzled amongst
COVID-19 protocols and the promotion turned to their home base of Las Vegas. They were originally expected to serve as the main event for a planned event on August 14, but the date was scrapped. Several bouts were also booked to take place at the planned August 14 event, before being rescheduled to this date: • A women's flyweight bout between
Taila Santos and Mandy Böhm. In turn, after the change in location, Santos was removed due to alleged
visa issues and replaced by former
KSW Women's Flyweight Champion Ariane Lipski. • A women's flyweight bout between
Molly McCann and
Ji Yeon Kim. • A featherweight bout featuring
Charles Jourdain and
Lerone Murphy. A flyweight bout between former
UFC Flyweight Championship challenger
Alex Perez and
Matt Schnell had been rescheduled for this event. They were originally expected to meet at
UFC 262, before Perez was forced to pull out due to undisclosed reasons. They were then booked again at
UFC on ESPN: Barboza vs. Chikadze, before being shifted to this event.
Nathaniel Wood was expected to face
Jonathan Martinez in a bantamweight bout at the event. However, Wood pulled out of the bout in mid-August citing a broken hand and was replaced by Marcelo Rojo. At the weigh-ins, Martinez weighed in at 138 pounds, two pounds over the bantamweight non-title fight limit. The bout was expected to proceed at a catchweight, but it was eventually scrapped hours later. A bantamweight bout between
Jack Shore and
Said Nurmagomedov was scheduled for the event. However, Nurmagomedov was pulled from the event due to visa issues and was replaced by Zviad Lazishvili. Lazishvili later pulled out due to injury and was replaced by Liudvik Sholinian. A light heavyweight bout between former
UFC Light Heavyweight Championship challenger
Alexander Gustafsson and
Paul Craig was expected to take place at the event. However, a week before the event, Gustafsson withdrew due to injury. In turn, promotion officials removed Craig from the card as well. A light heavyweight bout between former light heavyweight title challenger
Volkan Oezdemir and
Magomed Ankalaev was expected to take place at this event. However, the bout was postponed to
UFC 267 for unknown reasons. A welterweight bout between
David Zawada and
Sergey Khandozhko was expected to take place at the event. However, the week before the event, Khandozhko was pulled from the contest for unknown reasons and replaced by
Alex Morono. However, Pavlovich pulled out a week before the contest due to visa issues and was replaced by
Serghei Spivac. A lightweight bout between
Marc Diakiese and
Rafael Alves was scheduled for the event. However, Alves pulled out of the fight in mid-August for undisclosed reasons and in turn, Diakiese was removed from the card as well. ==Results==