In 1968, Perrine worked as a
showgirl in "Lido de Paris" at the
Stardust Resort and Casino in
Las Vegas. After several years in Las Vegas, Perrine moved to Los Angeles. "Acting wasn’t something I pursued," she later recalled. "I was at a small dinner party where an agent was looking for someone to play the role of Montana Wildhack in
George Roy Hill’s film production of
Slaughterhouse-Five. The agent saw something in me and thought I would be perfect for the part. That’s how I became an actress." Her performance as Montana Wildhack, a
softcore pornography actress, established Perrine as a rising actress in Hollywood. Perrine was photographed nude for a pictorial in the May 1972 issue of
Playboy, and she later appeared on the magazine's cover in August 1981. She became the first actress to appear nude intentionally on American network television during the May 4, 1973,
PBS broadcast of
Bruce Jay Friedman's
Steambath on
Hollywood Television Theater. Later in 1973, she appeared in the episode "When the Girls Came Out to Play" of the romantic anthology television series
Love Story (1973). In 1975, Perrine received an
Academy Award nomination for Best Actress and a
Golden Globe nomination for Best Motion Picture Actress (Drama), and she won the
Best Actress Award at the
Cannes Film Festival for her role portrayal of
Honey Bruce, the wife of comedian
Lenny Bruce, in
Bob Fosse's
Lenny (1974). She portrayed
Carlotta Monti, the longtime companion of
W. C. Fields, in the biographical film
W. C. Fields and Me (1976). Perrine then played Miss
Eve Teschmacher, the accomplice of criminal mastermind
Lex Luthor, in
Superman (1978), earning a 1979
Saturn Award nomination for Best Supporting Actress. She later reprised the role in the sequel
Superman II (1980). Perrine appeared as Charlotta Steele, the ex‑wife of a
rodeo champion played by
Robert Redford, in
The Electric Horseman (1979). Her career became more uneven after her role in ''
Can't Stop the Music (1980), for which she received a Razzie Award nomination for Worst Actress; the film has since developed a cult following. She played Marcy Smith, the wife of a corrupt police officer, in The Border (1982) with Jack Nicholson, and in 1986 starred opposite Harvey Korman in the short-lived CBS sitcom Leo & Liz in Beverly Hills''. In the following years, Perrine appeared in lower‑profile projects, though she had a small supporting role in
Mel Gibson's film
What Women Want (2000). In 1995, she guest‑starred on
Homicide: Life on the Street, playing an ex-wife of
Richard Belzer's character, Detective
John Munch. Stacey Souther directed and produced
Valerie, a 45-minute documentary about Perrine's career and her experience with Parkinson's disease. The film screened at the Edmonton Film Festival in 2020. ==Personal life==