In 1907, following Bulgarian complaints and Russian pressure, Karavangelis was removed from his position by orders of the
Sultan. He returned to Constantinople as a
Synod until the collapse of the
Diocese of
Amaseia in January 1908. The Patriarch had requested that Karavangelis fill the recently vacated position, and so he became the Metropolitan of Amaseia, based in
Sampsounta. There, he helped create schools in the most remote villages and established a high school for Greek education. He also assisted in the formation of armed groups to defend the Greek and
Armenian population from Turkish aggression and persecution by the
Young Turks. During
massacres of local Armenians, Karavangelis along with
Chrysanthos of Trebizond and Bishop Efthymios were able to save hundreds by hiding them in the Metropolitan Church and other Greek homes. Their efforts were recognized by a United States-based Armenian newspaper. For his actions, he was arrested and sent to Constantinople in 1917, where he would remain in prison for some time. Following his release and the intensification of the
Greco-Turkish War, he was sentenced to death in
absentia by
Mustafa Kemal's military tribunal in 1921. In the same year, Karavangelis proposed a Greek-Armenian-
Kurdish cooperation to subdue the Turkish Nationalist Movement, to the Greek Foreign Minister
Georgios Baltatzis. This, however, would not come to flourishment. He was also large advocate for a
Republic of Pontus which had made him an even larger target for the Turkish Nationalist forces. In August 1922, he was in
Bucharest for the coronation of
Ferdinand I of Romania when disaster struck the Greeks. He got on the first ship to Constantinople, however he was not permitted to leave the steamer by the troops of Kemal. He was given a letter by the Patriarch which had notified him that if he left the boat he would be arrested and executed. The Patriarch appointed him
Metropolitan of Ioannina for his own safety. == Later career and death ==