FLT1 is a member of
VEGF receptor gene family. It encodes a
receptor tyrosine kinase which is activated by
VEGF-A,
VEGF-B, and
placental growth factor. The sequence structure of the
FLT1 gene resembles that of the
FMS (now
CSF1R) gene; hence, Yoshida et al. (1987) proposed the name FLT as an acronym for FMS-like tyrosine kinase. The ablation of VEGFR1 by chemical and genetic means has also recently been found to augment the conversion of
white adipose tissue to
brown adipose tissue as well as increase brown adipose
angiogenesis in mice. Functional genetic variation in
FLT1 (rs9582036) has been found to affect
non-small cell lung cancer survival. == Interactions ==