Minor leagues in 2022 Pasquantino made his professional debut in 2019 with the Rookie-level
Burlington Royals, batting .294 with 14 home runs and 53
runs batted in (RBIs) over 57 games. He did not play in 2020 because the season was cancelled due to the
COVID-19 pandemic. He started the 2021 season with the Single-A
Quad Cities River Bandits before being promoted to the Double-A
Northwest Arkansas Naturals. Over 116 games between the two teams, he slashed .300/.394/.563 with 24 home runs, 84 RBIs, and 37 doubles. Pasquantino opened the 2022 season with the Triple-A
Omaha Storm Chasers. After the Royals traded first baseman
Carlos Santana on June 27, Pasquantino was promoted to the active roster.
Major leagues 2022 On July 1, 2022, Pasquantino hit a home run off of
Detroit Tigers starter
Michael Pineda for his first career major league hit. He hit his second career homer on July 11, coincidentally also off of Pineda. He was named the
American League Player of the Week for August 8 to 14 when he hit .455 with four home runs and six RBIs in six games.
2023 Pasquantino made the
Opening Day roster for Kansas City in 2023. Playing in 61 games, he hit .247/.324/.437 with 9 home runs and 26 RBI. The Royals organization started a continuing tradition of having a team employee dressed in a
bigfoot or sasquatch costume walk across the roof of the team hall of fame in left field each time Pasquantino reaches base; Pasquantino was not told by the team of the stunt beforehand, only learning of it when a friend sent him a link to a
tweet containing a clip of the event. Pasquantino has embraced it, along with his nickname of "Pasquatch," wearing a gold sasquatch necklace. The Royals have also arranged promotional Pasquatch-themed giveaways such as necklaces and small figurines. On June 14, 2023, it was announced that Pasquantino would undergo season–ending surgery to repair a torn
labrum in his right shoulder.
2024 Pasquantino began the 2024 season as the Royals' starting first baseman. During a game versus the
Houston Astros on August 29, Pasquantino suffered a broken right thumb when Astros catcher
Yainer Diaz ran into his outstretched hand as he attempted to field a throw from pitcher
Lucas Erceg. He underwent surgery which ended his regular season. He played in 131 regular season games in 2024, slashing a combined .262/.315/.446 with 19 home runs, and 97 RBIs. By the fall, Pasquantino's injury had healed to the point where the Royals added him to their
postseason roster on October 1, for their Wild Card round matchup against the
Baltimore Orioles. Playing in two games, he batted .286 with two hits and one RBI, also drawing two walks. With Pasquantino's input, the team introduced the "Pasqwich," an
Italian beef sandwich with
bacon,
hash brown patties, and
provolone cheese on a
brioche bun with a
giardiniera aioli, sold at "Pasquantino's," a themed
food cart inside the stadium. The cart continued for the 2025 season.
2025 Pasquantino began the 2025 season as the Royals' starting first baseman. On June 5, 2025, Pasquantino matched a career high with four hits in the first game of a doubleheader at the
St. Louis Cardinals. Between June 2–8, he went 13-for-26 with a double, two home runs, and 7 RBI in seven games, being named the
American League Player of the Week for that span. Between August 18 and August 22, Pasquantino homered in 5 straight games to match a franchise record, previously done by
Mike Sweeney from June 25–29, 2002 and
Salvador Perez from August 25–29, 2021. It was the second 5-game HR streak in the Majors this season, following Shohei Ohtani, who did it from July 19-23. Between August 18–24, he went 11-for-29 with two doubles, six home runs, and 12 RBI in seven games, being named the American League Player of the Week for that span. It is his third career American League Player of the Week honor, following June 2–8 this season and August 8–14, 2022. His three such awards are tied with
Carlos Beltrán for the 6th most in Royals history, trailing only
George Brett (12),
Hal McRae (5),
Billy Butler (5), Mike Sweeney (4), and
Bret Saberhagen (4). Pasquantino finished the 2025 season batting .264/.323/.475 in 160 games. He recorded 32 home runs and 113 RBI, the latter of which ranked third in the American League.
2026 Prior to the
2026 season, Pasquantino and the Royals
front office were unable to come to an agreement on contract terms prior to the January 8, 2026,
arbitration deadline. Pasquantino filed for a salary of $4.5 million, while the Royals filed for a salary of $4 million. ==International career==