Clarke worked for the British Electrical and Allied Manufacturers' Association, 1932–33. He was then on the staff of the
Financial News (later taken over by the
Financial Times) until 1939 and devised the Ordinary Share Index, now the
Financial Times Ordinary Share Index. During
World War II he served in the Ministries of Information, Economic Warfare, and Supply and Production, and with the
Combined Production and Resources Board in Washington, 1942–43. He joined the
Treasury in 1945 and was its
Second Permanent Secretary, 1962–66. He was then
Permanent Secretary at the
Ministry of Aviation in 1966, then at the
Ministry of Technology until 1970, retiring from the Civil Service in 1971. From 1973, he was a Vice-President of the
Royal Institution. According to
Sir Douglas Wass, Clarke was "a character you either loved and hated or hated" – although he himself stated "I loved him." Wass stated that, with the exception of
Sir Leo Pliatzky, Clarke held most ministers and colleagues "in high disesteem". ==Honours==