•
Thomas Samuel Ashe,
congressman from North Carolina; practiced law in Wadesboro •
Hugh Hammond Bennett, founder of the Soil Conservation Service, now
Natural Resources Conservation Service, president of the
Association of American Geographers •
Risden Tyler Bennett, congressman •
Tom Brewer, baseball player •
John Culpepper, congressman from North Carolina •
Edmund Strother Dargan, congressman from Alabama and representative to the
Confederate States Congress during the American Civil War •
Thomas F. Davis, fifth
Episcopal bishop of South Carolina; deacon at Calvary Church in Wadesboro •
Ed Emory, football player and coach •
Blind Boy Fuller, musician •
John Gaddy, baseball player •
Pryor A. Gibson, III, eight-term member of
North Carolina General Assembly •
John T. Henley, member of the North Carolina House of Representatives and
North Carolina Senate •
Timmy Horne, nose tackle for the
Atlanta Falcons •
Alvin Paul Kitchin, congressman from North Carolina; practiced law in Wadesboro •
Leon Levine, founder of
Family Dollar variety store chain •
James A. Lockhart, congressman from North Carolina; lived in Wadesboro •
Elizabeth Reid Murray, historian and preservationist •
Gary Porter, former driver of the
Carolina Crusher and
Grave Digger Monster Truck •
Sylvester "Junkyard Dog" Ritter, professional wrestler •
Cornelius Robinson, member of Provisional Confederate Congress •
Leonidas D. Robinson, congressman from North Carolina •
Jerome Robinson, baseball player •
Will Robinson, basketball player •
Trinton Sturdivant, football player •
Hoyt Patrick Taylor, 21st lieutenant governor of North Carolina; former mayor of Wadesboro •
Hoyt Patrick Taylor Jr., speaker of the North Carolina House of Representatives and 26th lieutenant governor of North Carolina •
William L. Terry, congressman from Arkansas •
John Threadgill, Oklahoma and Texas politician •
Colonel Thomas Wade, Revolutionary War hero and legislator ==In popular culture==