Having arrived in
Malacca, Medhurst learned
Malay, and studied
Chinese,
Chinese characters, and the
Hokkien group of
Min Nan Chinese varieties, which is widely spoken in Southeast Asia. He was ordained there by
William Charles Milne on 27 April 1819. Their youngest daughter was Augusta, born in 1840. Today's
All Saints Church, Jakarta and the Parapattan Orphanage were started by Medhurst. In addition to compiling his Chinese-English and English-Chinese dictionaries, Medhurst was a prolific translator, lexicographer, and editor. Although Medhurst never traveled to Japan, in 1830 he published
An English and Japanese, and Japanese and English Vocabulary Compiled from Native Works in 344 pages. Based upon his studies of Hokkien, in 1831 Medhurst completed his
A Dictionary of the Hok-këèn Dialect of the Chinese Language, but printing of all 862 pages of which reached finality only in 1837 after being affected by the end of the
British East India Company's trade monopoly in 1834 and for lack of funds. In the 1840s, Medhurst collaborated with
John Stronach,
Elijah Coleman Bridgman, and
William Charles Milne translating the (1847) "Delegates' Version" of the
Bible in Chinese. Medhurst,
Elihu Doty, and
John Van Nest Talmage developed the
Pe̍h-ōe-jī Church Romanization of
Southern Min Chinese that was widely used by missionaries. When peace was concluded with China in 1842, he moved to
Shanghai where he founded the
London Missionary Society Press () together with
William Muirhead and
Dr William Lockhart. They were later joined by
Joseph Edkins, and
William Charles Milne. He continued in Shanghai until 1856, laying the foundations of a successful mission. In 1843,
New York University conferred upon him the honorary degree of
D.D. ==Delegates' Version==