Wang Can was from Gaoping County (),
Shanyang Commandery (), which is around present-day
Weishan County, Shandong. He was born in a family of high-ranking officials as a son of Wang Qian (), a Chief Clerk () to the general
He Jin, who was briefly a regent for
Emperor Shao in 189. Wang Can's great-grandfather, Wang Gong (), and grandfather, Wang Chang (), held offices among the
Three Ducal Ministers during the reigns of
Emperor Shun and
Emperor Ling respectively. When the warlord and regent
Dong Zhuo usurped power in 189, placing on the throne the puppet ruler
Emperor Xian, Wang Can was merely 13 years old (by East Asian reckoning). A year later, Dong Zhuo moved the imperial capital from
Luoyang to the more strategically secure
Chang'an. Wang Can then headed to Chang'an, where he settled down for the next three years. In Chang'an, the prominent scholar and calligrapher
Cai Yong recognised Wang Can's talent and recommended him to the civil service. Wang Can received several offers to serve in the government, but he turned down all of them. In 194, Wang Can went to
Jing Province (covering present-day
Hubei and
Hunan) to seek a position under the provincial governor,
Liu Biao. However, Liu Biao did not favour Wang Can as the latter looked pallid and sickly. After Liu Biao died in 208, Wang Can persuaded his son and successor,
Liu Cong, to surrender to
Cao Cao, the warlord who controlled the Han central government at the time. Wang Can's talents came to fruition during his service in Cao Cao's administration. In 213, after Emperor Xian enfeoffed Cao Cao as the Duke of Wei and granted him ten cities to form his dukedom, Cao Cao tasked Wang Can with establishing a new system of laws and standards to replace the old one, which had largely fallen into disuse. In late 216, Wang Can accompanied Cao Cao on his fourth campaign against a rival warlord,
Sun Quan. Wang Can died of illness on the way back to
Ye city (in present-day
Handan,
Hebei) in the spring of 217 at the age of 41 (by
East Asian age reckoning). Cao Cao's heir apparent,
Cao Pi, attended Wang Can's funeral and told the guests, "When he was still living, Wang Can loved the sounds of a donkey braying, so let's each make a braying sound as a farewell to him". Every guest did that. Wang Can had two sons, who were executed in 219 for participating in a rebellion led by
Wei Feng against Cao Cao's government. Their deaths resulted in the termination of Wang Can's family line. However, Wang Ye (; courtesy name Zhangxu), a younger relative of Wang Can, was eventually designated as Wang Can's adopted son and heir to continue his family line. Wang Ye inherited about 10,000 volumes of Wang Can's books (including books from Cai Yong's collection) and passed them on to his own sons,
Wang Bi and Bi's elder brother Wang Hong (). ==Literary achievements==