PR 481 begins on the boundary between the Rural Municipalities of
Mossey River and
Lakeshore at an intersection with
PR 364 in the hamlet of
Weiden. Travelling through a mix of farmland and wooded areas, it heads north for a short distance before curving due eastward and intersects
PR 490 a short time later. After a few kilometres, the highway enters
Toutes Aides, travelling along the south side of town as it shares a short
concurrency with
PR 276 and crosses a couple of creeks. Leaving Toutes Aides, PR 481 heads northeast via a couple switchbacks through wooded areas before meeting the coastline of
Lake Manitoba as it enters the town of
Crane River, turning sharply southward as it travels through town. It then crosses a bridge over the
Crane River to leave the town and enter the neighbouring
O-Chi-Chak-Ko-Sipi First Nation, almost immediately making an abrupt right turn to travel southward through neighbourhoods along the riverbank. The highway heads south through remote woodlands for several kilometres to join the coastline again, now winding its way southeast through farmland to pass through the communities of
Guynemer,
Cayer, and
Moore Dale, before coming to an end at a junction with
PTH 68 (
Northern Woods and Water Route) just as its entering the hamlet of
Eddystone. Excluding the short concurrency with PR 276 in Toutes Aides, the entire length of PR 481 is a gravel, two-lane highway. ==Major intersections==