Main •
Jane Levy as Lisa Ruiz-Donovan, the
CEO and founder of a biotech
startup called Emigen Molecular Sequencing •
Blake Jenner as Sean Donovan, Lisa's husband. A former pitcher for the
San Francisco Giants, he now works as an
EMT. •
Keith Powers as Todd Archer, Sean's best friend since high school. He works with Sean as a fellow EMT. •
Samantha Marie Ware as Angela Archer, Todd's wife. A
surgical resident, she has been having an affair with Ian Evans. • Juan Castano as Marcos Ruiz, Lisa's brother and an attorney •
Dave Annable as Dr. Ian Evans, the chief of surgery, who has been having an affair with Angela Archer •
Saamer Usmani as Avery Watkins, the new
COO of Emigen Molecular Sequencing •
Daniella Pineda as Cassidy Barrett, Lisa's best friend and the
CFO of Emigen Molecular Sequencing •
John Clarence Stewart as Lionel, Marcos' boyfriend and a real estate broker •
Louis Herthum as Foster, Anne's right-hand man •
Renée Zellweger as Anne Montgomery, a
venture capitalist based in
San Francisco Recurring • Derek Smith as Kevin, a go-go boy with whom Marcos and Lionel have slept with • Nana Ghana as Sophie • Monique Kim as Miles •
Allie MacDonald as Maddie Carter, Sean's ex-girlfriend •
Gabriel Mann as Gage Scott, Anne's business frenemy •
Julian Sands as Liam Strom, Anne's financial backer and mentor
Guest • Marissa Cuevas as Christine, a former high-school cheer captain •
Keegan Allen as Billy, Christine's ex-boyfriend from high school and a commercial director ==Production==