In 2002, Annable made his acting debut in an episode of the
NBC crime drama
Third Watch. Annable has appeared in numerous commercials for brands such as
Mountain Dew,
Starburst and
Abercrombie and Fitch. In 2004, Annable appeared in the films
Little Black Book and
Spellbound. In September 2005, Annable began appearing as Aaron Lewis on the
Fox drama series
Reunion, which centers on six friends who attend their 20th high school reunion, where one of them is murdered and all of them are suspects. In December, Fox cancelled the series due to low ratings shortly after the ninth episode aired.
The WB reportedly showed interest in picking up the series on their network, but these plans never materialized. In 2006, Annable was cast as
Justin Walker on the
ABC drama series
Brothers & Sisters alongside
Calista Flockhart,
Rachel Griffiths, and
Sally Field, which was picked up for a full season by the network. In 2007, Annable was ranked as #7 on
People magazine's annual list of Sexiest Men Alive. In 2008, Annable won a Prism Award for Best Performance in a Drama Series Multi-Episode Storyline for his portrayal on
Brothers & Sisters. The series ran for five seasons until 2011. In January 2012, Annable was confirmed to star as the male protagonist on the ABC supernatural drama series
666 Park Avenue alongside
Rachael Taylor,
Vanessa Williams and
Robert Buckley, which was picked up for a first season of 13 episodes in May. The series debuted in September only to be cancelled by November and removed from the network's schedule in December.
666 Park Avenue returned to ABC in June 2013 to
burn off its remaining episodes. In 2014, Annable starred on the
Fox series
Red Band Society, where he played the role of pediatric oncologist and surgeon Dr. Adam McAndrew. In 2016, he appeared as Pierce Harris on the
NBC medical drama
Heartbeat alongside
Melissa George and
Don Hany. Both series were also cancelled after one season. In 2016, he landed recurring role as Teddy Grant on
Fox's comedy series
The Mick alongside
Kaitlin Olson. On April 5, 2016, it was announced that Annable joined the
WWE Studio action film
Armed Response alongside
Wesley Snipes and
Anne Heche. The movie was released in theaters on August 4, 2017. He also starred as author
Joe McGinniss in Jeffrey MacDonald true crime murder movie
Final Vision on
Investigation Discovery. On August 3, 2017, Annable was cast as Lee Dutton, a cowboy who serves as his father's (
Kevin Costner) right-hand man in running the ranch, in the pilot episode of
Paramount Network's period drama
Yellowstone. He starred as Billy opposite his real life wife
Odette Annable in a
Freeform holiday movie ''No Sleep 'Til Christmas.'' In 2019, Annable played the role of Dr. Ian Harris in Netflix's social thriller
What/If . In 2020, he guest starred as Kirby in an episode of
NBC drama series
This Is Us. ==Personal life==