Ganong undertook historical work during his teaching career. In summers, he would return to New Brunswick to study and document the historical geography of the province. Among his surveys were
St. Croix Island, site of
Champlain's first settlement in North America in 1604. He acquired a working knowledge of the Maliseet and Mi'kmaq languages, and with that understanding and consultation with linguists and native historians, he undertook an investigation of the aboriginal place names in the Maritime Provinces, publishing a series of six articles in the
Transactions of the Royal Society of Canada between 1911 and 1928. In 1889 he presented a paper on the cartography of the Gulf of Saint Lawrence from the 1530s to 1604. Later, in the 1930s, he published an additional nine articles in the
Transactions on what he termed the crucial maps in the early cartography and place-nomenclature of the region. The articles were drawn together and published in book form by the University of Toronto Press in 1964. His work on place-nomenclature is still widely referenced. In his explorations, he also had a chance to name several geographical features in the largely unexplored central and northern parts of New Brunswick, including
Mount Carleton, the highest summit in the province, which he named after the first Lieutenant-Governor of New Brunswick,
Thomas Carleton. Another mountain to the north of Mount Carleton was named for Ganong in 1901 by his friend and naturalist Mauran Furbish. As a scientist, Ganong brought a special quality to the study of New Brunswick history, which featured an emphasis on map-based studies and in determining the exact location of key historic sites. He actually went to the places he wrote about. As a translator and editor of the 17th-century
Acadian narratives of
Nicolas Denys and Father
Chrétien Le Clercq he became a foremost scholar of the Acadian period. He frequently contributed articles on Samuel de Champlain to publications of the New Brunswick Historical Society, the
New Brunswick Magazine and
Acadiensis. In addition to document-based research and translation, Ganong prepared maps, took photographs and gave slide presentations. He often collaborated with others. One frequent collaborator was
John Clarence Webster, for whom he prepared numerous maps and other contributions. He also took a great interest in the international border between New Brunswick and Maine. Because of this interest and expertise he was asked to take part in the cross-border tercentennial celebrations on the
St. Croix River in 1904. In 1918, Ganong completed the translation of Volume III of Champlain's
Voyages, part of a major publication of Champlain's writings by the Champlain Society. He was also the first to pose a scientific explanation for the often sighted
Ghost Ship of Northumberland Strait suggesting it was an electrical illusion. William F. Ganong's efforts also formed a substantial basis for the establishment of the
New Brunswick Museum and archives. Ganong died at his summer home outside Saint John in 1941. He was 77. ==Honours==