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William Lewis (pirate) (fl. 1687-?), English pirate (possibly fictional) •
William Lewis (judge) (1752–1819), United States federal judge •
William Terrell Lewis (1757–1813), Tennessee businessman •
William Lewis (militia officer) (c. 1767–1825), American militia officer •
William Berkeley Lewis (1784–1866), confidant of Andrew Jackson and auditor of the U.S. Treasury •
William B. Lewis (New York treasurer) (c. 1816–1884), New York State treasurer, 1862–1863 •
William Garrett Lewis (1821–1885), British Baptist preacher •
William G. Lewis (1835–1901), Confederate States Army officer •
William Draper Lewis (1867–1949), dean of the University of Pennsylvania Law School; founding director of the American Law Institute •
William Mather Lewis (1878–1945), president of George Washington and Lafayette Universities and government official •
William F. Lewis (1902–1964), Episcopal bishop • Sir
W. Arthur Lewis (William Arthur Lewis, 1915–1991), Saint Lucian economist == Companies ==