Rice served as professor of geology and natural history at
Wesleyan beginning in 1868. Early in his career he was ordained as a minister, joining the New England Conference of the
Methodist Episcopal Church. During the early 1870s, Rice undertook zoological research work with
Spencer Baird at the newly established laboratory of the
United States Fish Commission at
Woods Hole, Massachusetts. Later in the winter 1876 to 1877, he was part of a major geological and zoological expedition to Bermuda, one of the first expeditions of its type undertaken by American scientists. In the early 1880s, Rice took an interest in the geology of Europe, traveling for research activities there in 1881 and 1884. He continued further work with European colleagues in an extended trip to Germany from 1892 to 1893, and in later to France in 1900. Beginning in 1891, Rice took an active interest in the geology of the American West, traveling to
Yellowstone National Park and other
Rocky Mountain locations as part of an international geological expedition. Later in 1904, he conducted research in the
Grand Canyon and
Mexico, and later in that decade he traveled to
Alaska to study the glaciers of
Yakutat Bay. Rice served as an assistant geologist with the
U.S. Geological Survey, mapping the geological features of Connecticut. Later from 1903 to 1918, he served as Superintendent of the State Geological and Natural History Survey of Connecticut. In addition to his scientific studies, Rice took a keen interest in issues of science and religion. He was a lecturer on the relations of religion and science at the
Hamilton Theological Seminary at
Colgate University between 1897 and 1900. Throughout his career he wrote a number of landmark articles and books on the reconciliation of science with religious faith. Rice was active as an officer within scientific societies. In 1891, he served as the president of the
American Society of Naturalists. Later, from 1905 to 1906, he served as the vice president of the
American Association for the Advancement of Science, while concurrently serving as the chairman of the Geological Sciences division of that organization. Rice was also active in his local community by serving as a member of the Middletown Board of Education from 1884 to 1891; presiding over the board from 1885 to 1891. Later, from 1902 to 1905, he served as the president of the statewide Connecticut Council of Education. He was a member of the
Connecticut Academy of Arts and Sciences. Rice served as acting president of Wesleyan University on three occasions in 1907, from 1908 to 1909, and again in 1918. Shortly after his last stint as acting president in 1918, he retired from teaching, but continued much of his research and academic work as an emeritus professor. Later in his retirement, he moved to
Delaware, Ohio, to live with his son and his family. He died November 13, 1928, in
Delaware, Ohio. ==Family life==