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William West (Rhode Island politician) (c. 1733–1816), American militia general in the American Revolutionary War and later political leader •
William West, 1st Baron De La Warr (c. 1520–1595), British political figure •
William H. West (judge) (1824–1911), politician and member of the Ohio Supreme Court, 1872–1873 •
William H. West (policeman) (1842–1915), soldier and police officer •
William H. West (Louisiana politician) (1928-2016), American politician and educator •
William West (legal writer) (c. 1548–1598), English lawyer, known as the author of
Symbolæographia •
William Stanley West (1849–1914), U.S. Senator from Georgia •
William West (1612–1670), English politician •
William J. West (Canadian politician) (1892–1985), member of the Legislative Assembly of New Brunswick •
William J. West (UK politician) (1868–?), British politician and trade unionist ==Science==