The painting dates from Caravaggio's first years in Rome following his arrival from his native
Milan in mid-1592. Sources for this period are inconclusive and probably inaccurate, but they agree that at one point the artist fell extremely ill and spent six months in the hospital of Santa Maria della Consolazione. According to a 2009 article in the American medical publication
Clinical Infectious Diseases, the painting indicates that Caravaggio's physical ailment likely involved
malaria, as the
jaundiced appearance of the skin and the
icterus in the eyes are indications of some active
hepatic disease causing high levels of
bilirubin. According to
Paolo Zamboni professor of Vascular Surgery at
University of Ferrara, the obvious signs of
anemia, yellow skin, and
acanthosis nigricans lead back to the diagnosis in painting of
Addison's disease, a condition described by Addison in the 1800s that affects the adrenal glands. The
Sick Bacchus was among the many works making up the collection of
Giuseppe Cesari, one of Caravaggio's early employers, which was seized by the art-collector
Cardinal-Nephew Scipione Borghese in 1607, together with the
Boy Peeling Fruit and
Boy with a Basket of Fruit. ==Style==