at the 25th
Spirit Awards in 2010 Cregger is a founding member of the Whitest Kids U' Know comedy troupe, formed alongside
Trevor Moore and Sam Brown in 2000. While shooting an independent film, he met Darren Trumeter who subsequently joined the group. The Whitest Kids U' Know garnered success locally and online, leading to an invitation to the HBO
U.S. Comedy Arts Festival in 2006. The troupe won the award for Best
Sketch Group and attracted the attention of several networks. Following their successful showcase,
Fuse ordered a sketch series from the group. ''The Whitest Kids U' Know'' aired its first season on the network in 2007 before moving to then-sister network
IFC. The series ran for five seasons before concluding in 2011. Alongside Moore, he starred in and co-directed the films
Miss March and
The Civil War on Drugs. The latter received a limited theatrical release and aired as a recurring
serial during the final season of ''The Whitest Kids U' Know''. The troupe's second feature film,
Mars, premiered at the
Tribeca Festival on June 6, 2024. In 2008, Cregger made his first film appearance in Deb Hagan's directorial debut
College. In 2011, he joined the cast of the
NBC sitcom
Friends with Benefits. He then starred on the NBC sitcom
Guys with Kids from 2012 to 2013. From 2016 to 2018, he starred as Owen O'Connor on the
TBS sitcom
Wrecked. Cregger wrote and directed the 2022 horror film
Barbarian, starring
Georgina Campbell,
Bill Skarsgård, and
Justin Long. He wrote and directed the 2025 horror film
Weapons, which garnered critical acclaim and several accolades, including the
Academy Award for Best Supporting Actress for
Amy Madigan. In January 2025, it was announced that Cregger would write and direct
an upcoming horror film based on the
Resident Evil video game franchise from
Capcom. In December 2025, it was announced that he will serve as a producer on a feature film adaptation of
Torso for
Netflix. At the
Warner Bros. Pictures panel at
CinemaCon 2026, a new film directed by Cregger, the science fiction thriller
The Flood, was announced, which is set for release on August 11, 2028, which is set to be co-produced with
Amblin Entertainment. In that same panel, New Line announced a
Weapons prequel titled
Gladys, set for release on September 8, 2028, which is expected to be co-written with Zach Shields, but will not be directed by Cregger. ==Personal life==