The mail route from Nenana to Nome spanned in total. It crossed the barren Alaska Interior, following the
Tanana River for to the village
Tanana at the junction with the
Yukon River, and then following the Yukon for to
Kaltag. The route then passed west over the Kaltag Portage to
Unalakleet on the shore of
Norton Sound. The route then continued for northwest around the southern shore of the Seward Peninsula with no protection from gales and blizzards, including a stretch across the shifting ice of the
Bering Sea. Edward Wetzler, the
US Postal Service inspector for Nenana, contacted Tom Parson, an agent of the Northern Commercial Company, contracted to deliver mail between Fairbanks and Unalakleet. Telephones and telegraphs turned the drivers back to their assigned
roadhouses. The mail carriers held a revered position in the territory, and were the best dog mushers in Alaska. The majority of relay drivers across the Interior were native
Athabaskans, direct descendants of the original dog mushers. The first musher in the relay was "Wild Bill" Shannon, who was handed the package at the train station in Nenana on January 27 at 9:00 pm
AKST by night. Despite a temperature of , Shannon left immediately with his team of 9 inexperienced dogs, led by Blackie. The temperature began to drop, and the team was forced onto the colder ice of the river because the trail had been destroyed by horses. Despite jogging alongside the sled to keep warm, Shannon developed
hypothermia. He reached
Minto at 3 am, with parts of his face black from
frostbite. The temperature was . After warming the serum by the fire and resting for four hours, Shannon dropped three dogs and left with the remaining 8. The three dogs died shortly after Shannon returned for them, and a fourth may have died as well.
Arrival in Minto Half-Athabaskan Edgar Kalland arrived in Minto the night before, and was sent back to Tolovana, traveling the day before the relay. Shannon and his team arrived in bad condition at 11 am, and handed over the serum. After warming the serum in the roadhouse, Kalland headed into the forest. The temperature had fallen to , causing Kalland's hands to freeze to the sled's handlebar, requiring the owner of the Manley Hot Springs roadhouse to pour boiling water on the birch wood bar for thawing. No new cases of diphtheria were diagnosed on January 28, but two new cases were diagnosed on January 29. The quarantine had been obeyed, but lack of diagnostic tools and the contagiousness of the strain rendered it ineffective. More units of serum were discovered around Juneau the same day. While no count exists, the estimate based on weight is roughly 125,000 units, enough to treat 4 to 6 patients. The crisis had become headline news in newspapers, including in
San Francisco,
Cleveland,
Washington D.C., and
New York, and spread to the radio sets which were just becoming common. The storm system from Alaska hit the contiguous United States, bringing record lows to New York, and freezing the
Hudson River. A fifth death occurred on January 30. Maynard and Alaskan House Delegate
Daniel Sutherland renewed their campaign for flying the remaining serum by plane. Different proposals included flying a large aircraft from Seattle to Nome, carrying a plane to the edge of the
pack ice via Navy ship and launching it, and the original plan of flying the serum from Fairbanks. Despite receiving headline coverage across the country and support from Arctic explorer
Roald Amundsen, the plans were rejected by experienced pilots, the Navy, and Governor Bone. As publisher and editor of the
Fairbanks Daily News-Miner newspaper, William Fentress Thompson harshly criticized government officials for inaction and funded a private fleet of planes. In response, Governor Bone decided to speed up the relay, authorizing additional drivers for Seppala's leg of the relay, so they could travel without rest. Seppala was still scheduled to cover the most dangerous leg, the shortcut across
Norton Sound, but the telephone and
telegraph systems bypassed the small villages he was passing through, and there was no way to tell him to wait at
Shaktoolik. The plan relied on the driver from the north catching Seppala on the trail. Summers arranged for drivers along the last leg, including Seppala's colleague
Gunnar Kaasen. From
Manley Hot Springs, the serum passed through largely Athabascan hands before George Nollner delivered it to Charlie Evans at Bishop Mountain on January 30 at 3 am. The temperature had warmed slightly, but at , was dropping again. Evans relied on his lead dogs when he passed through
ice fog where the
Koyukuk River, flowing into the Yukon, had broken through and surged over the ice, but forgot to protect the groins of his two short-haired mixed breed lead dogs with rabbit skins. Both dogs collapsed with frostbite, with Evans having to take their place himself pulling the sled. He arrived at 10 am; both dogs were dead. Tommy Patsy departed within half an hour. The transport of the serum then parted ways with the Yukon River as the river turned south and the trail crossed the Kaltag Portage west to the coast. Athabascan Jack Nicolai, aka "Jackscrew", took it up the first half of the portage to Old Woman Cabin and Victor Anagick of the Inupiat village
Unalakleet, having driven up to meet him there, took it down the second half, handing it to his fellow villager Myles Gonangnan on the shores of Norton Sound in Unalakleet on January 31 at 5 am. Gonangnan saw the signs of a storm brewing, and decided not to take the shortcut across the dangerous ice of the Sound. He departed at 5:30 am, and as he crossed the hills, "the eddies of drifting, swirling snow passing between the dog's legs and under the bellies made them appear to be fording a fast running river." The
whiteout conditions cleared as he reached the shore, and the gale-force winds drove the wind chill to . At 3 pm, he arrived at Shaktoolik. Seppala was not there, but Henry Ivanoff was waiting just in case. On January 30, the number of cases in Nome had reached 27 and the antitoxin was depleted. According to a reporter living in Nome, "All hope is in the dogs and their heroic drivers ... Nome appears to be a deserted city." With the report of Gonangnan's progress on January 31, Welch believed the serum would arrive there in February.
Connection on Norton Sound with his dogs after the serum run in 1925. His lead dog,
Togo, is on the far left. Leonhard Seppala and his dog sled team, with his lead dog Togo, travelled from Nome from January 27 to January 31 into the oncoming storm. They took the shortcut across the Norton Sound, and headed toward Shaktoolik. The temperature in Nome was a relatively warm , but in Shaktoolik, the temperature was estimated at , and the
gale force winds causing a
wind chill of . Henry Ivanoff's team ran into a reindeer and got tangled up just outside
Shaktoolik. Seppala still believed he had more than to the original relay point in Nulato to go and had raced to get off the Norton Sound before the storm hit. He was passing the team when Ivanoff shouted, "The serum! The serum! I have it here!" Seppala turned around with the serum but it was dark by the time he got to Ungalik. But with the news of the worsening epidemic Ivanoff had shared, he decided not to stop and once again set out to brave the storm across the of exposed open ice of the
Norton Sound. The temperature was estimated at , but the
wind chill with the
gale force winds was . Togo led the team in a straight line through the dark, and they arrived at the roadhouse in Isaac's Point on the other side at 8 pm. In one day, they had travelled , averaging . The team rested, and departed at 2 am into the full power of the storm. During the night, the temperature dropped to , and the wind increased to storm force (at least ). While they slept, it had blown out to sea all the ice Seppala had just crossed. There was still some ice close to shore for the next part of their journey along the coast, but it was rough and starting to break up too. They stuck close to shore, and Togo picked his way carefully until they were back on solid ground. Next they had to cross Little McKinley Mountain (), another of the toughest parts of the trail because of the many up-and-down ridges. The total elevation climbed in that section of over is . After descending to the next roadhouse in
Golovin, Seppala passed the serum to Charlie Olsen on February 1 at 3 pm. On February 1, the number of cases in Nome rose to 28. The serum en route was sufficient to treat 30 people. With the powerful blizzard raging and winds of , Welch ordered a stop to the relay until the storm passed, reasoning that a delay was better than the risk of losing all the serum. Messages were left at Solomon and Point Safety before the lines went dead. Olsen was blown off the trail, and suffered severe frostbite in his hands while putting blankets on his dogs. The wind chill was . He arrived at Bluff on February 1 at 7 pm in poor condition.
Gunnar Kaasen waited until 10 pm for the storm to break, but it only got worse and the drifts would soon block the trail, so he departed into a
headwind. with
Balto, the lead dog for the team he drove in the serum run Kaasen traveled through the night, through drifts, and river overflow over the Topkok Mountain.
Balto led the team through visibility so poor that Kaasen could not always see the dogs harnessed closest to the sled. He was two miles (3 km) past Solomon before he realized it, and kept going. The winds after Solomon were so severe that his sled flipped over and he almost lost the cylinder containing the serum when it fell off and became buried in the snow. He also suffered frostbite when he had to use his bare hands to feel for the cylinder. Kaasen reached Point Safety ahead of schedule on February 2, at 3 am. Ed Rohn believed that Kaasen and the relay had halted at Solomon, so he was sleeping. Since the weather was improving, it would take time to prepare Rohn's team, and Balto and the other dogs were moving well, Kaasen pressed on with the remaining to Nome, reaching Front Street at 5:30 am. Not a single
ampule was broken, and the antitoxin was thawed and ready by noon. Together, the teams covered the in 127 hours, which was considered a world record, done in extreme subzero temperatures in near-
blizzard conditions and
hurricane-force winds. A number of dogs died during the trip. == Second relay ==