The following is a list of notable players (winners of a main tour title, and/or part of the ATP rankings top 100 in singles, or top 100 in doubles, for at least one week) who announced their retirement from professional tennis, became inactive (after not playing for more than 52 weeks), or were permanently banned from playing, during the 2021 season: •
Alexandr Dolgopolov (born 7 November 1988 in Kyiv, Ukraine) joined the professional tour in 2006 and reached a career-high ranking of No. 13 in singles and No. 42 in doubles, both in January 2012. He won three titles in singles and one title in doubles, as well as reaching one
Grand Slam quarterfinal in singles. Having been inactive since his wrist injury in 2018 including his attempted comeback which was slated in 2020, Dolgopolov announced his retirement from the
ATP Tour in May 2021. •
Jared Donaldson (born 9 October 1996 in Providence, United States) joined the professional tour in 2014 and with a career-high ranking of No. 48 in singles in March 2018. He announced his retirement in December 2021 due to surgeries in the last two years and decided to start his collegiate education. •
Guillermo García López (born 4 June 1983 in La Roda, Spain) joined the professional tour in 2002 and reached a career-high ranking of No. 23 in singles in February 2011 and No. 27 in doubles in May 2017. He won five titles in singles and played for the
Spanish Davis Cup team. In doubles, he won three titles, reached the final of the
2016 US Open and the semifinals of the
2017 Australian Open. In January 2021, he announced that he would retire after the 2021 season. •
Daniel Gimeno Traver (born 7 August 1985 in Valencia, Spain) joined the professional tour in 2004 and reached a career-high ranking of No. 48 in singles in March 2013 and No. 63 in doubles in February 2012. He won one title in doubles. Gimeno Traver retired from professional tennis in the season. •
Martin Kližan (born 11 July 1989 in Bratislava, Czechoslovakia (now Slovakia)) joined the professional tour in 2007 and reached a career-high ranking of No. 24 in singles in April 2015 and No. 73 in doubles in May 2015. He won six titles in singles and four titles in doubles. He also won the
2006 Junior French Open and achieved world No. 1 on the junior circuit in January 2007. He won two of his titles at
ATP 500 level (
Rotterdam 2016 and
Hamburg 2016) and recorded four victories over top-10 players with his most notable being against
Rafael Nadal at
Beijing 2014 who was ranked No. 2 in the world at the time. He played his last match at
2021 Wimbledon qualifying where he lost in the first round to
Zdeněk Kolář. He announced his retirement in August. •
Julian Knowle (born 29 April 1974 in Lauterach, Austria), former World No. 6 in doubles, won 19 doubles titles. •
Robert Lindstedt (born 19 March 1977 in Sundbyberg, Sweden), former World No. 3 in doubles, won 23 doubles titles. His last ATP tournament in his career was the
2021 Stockholm Open. •
Paolo Lorenzi (born 15 December 1981 in Rome, Italy) joined the professional tour in 1999 and reached a career-high ranking of No. 33 in singles in May 2017 and No. 82 in doubles in January 2018. He won one title in singles and one in doubles. He won 21
ATP Challenger Tour titles (third in the all-time leaderboard). He was part of the
Italian Davis Cup team. Lorenzi announced the
2021 US Open would be his last professional tournament, and he lost to
Maxime Janvier in the second qualifying round. •
Lu Yen-hsun (born 14 August 1983 in Taipei, Taiwan) joined the professional tour in 2001 and reached a career-high ranking of No. 33 in singles in November 2010 and No. 86 in doubles in January 2005. In singles, he won 29 challenger titles, the most anyone has won, and reached the Quarterfinals in the
2010 Wimbledon Championships. Lu announced in June that Wimbledon and the Tokyo Olympics would be his last tournaments on the tour. •
Leonardo Mayer (born 15 May 1987 in Corrientes, Argentina]) joined the professional tour in 2003 and reached a career-high ranking of No. 21 in singles in June 2015 and No. 48 in doubles in January 2019. He won two titles in singles, both times at the
German Open. Mayer retired from tennis in October 2021. •
Jürgen Melzer (born 22 May 1981 in Deutsch-Wagram, Austria) joined the professional tour in 1999 and reached a career-high ranking of No. 8 in singles in April 2011 and No. 6 in doubles in November 2010. He won five titles in singles and reached the semifinals of the
2010 French Open. In doubles, he won 17 titles, including the
2010 Wimbledon Championships and the
2011 US Open. Melzer retired from singles in October 2018, but continued to play doubles competitions on the ATP Tour afterwards. In October 2020, he announced that the
2021 Australian Open would be his last professional tournament. However, he did not play the
Australian Open due to the COVID-19 quarantine measures and instead played at the
French Open,
Wimbledon and the
US Open. He played his final tournament on the ATP Tour at the
Vienna Open, where he partnered
Alexander Zverev. •
Viktor Troicki (born 10 February 1986 in Belgrade, SR Serbia, Yugoslavia (now Serbia)) joined the professional tour in 2006 and reached a career-high ranking of 12 in singles in June 2011 and 49 in doubles in October 2010. He won three titles in singles and 2 in doubles. In team competitions, he was part of the
Serbia Davis Cup team who won the
Davis Cup in 2010, as well as part of the Serbian team who won the inaugural
ATP Cup in 2020. Troicki announced on 17 June 2021 that Wimbledon would be his last professional tournament. •
Luca Vanni (born 4 June 1985 in Castel del Piano, Italy) joined the professional tour in 2006 and reached a career-high ranking of No. 100 in singles in May 2015.
Inactivity •
Sanchai Ratiwatana became inactive after not playing for more than a year. ==Comebacks==