Eastern Conference first round (A1) Florida Panthers vs. (WC2) Washington Capitals The Florida Panthers earned the
Presidents' Trophy as the NHL's best regular season team with 122 points. Washington finished as the Eastern Conference's second wild card, earning 100 points. This was the first playoff meeting between these two teams. Florida won two of the three games in this year's regular season series. The Panthers defeated the Capitals in six games and won their first playoff series since
1996. In game one, the Capitals overcame a one-goal deficit in the third period and gained the lead at 10:37 on
T. J. Oshie's goal to win 4–2.
Aleksander Barkov and
Carter Verhaeghe both scored a goal and provided an assist in the Panthers' 5–1 victory in game two.
Ilya Samsonov made 29 saves for the Capitals in game three, outscoring the Panthers 6–1 and taking a 2–1 series lead. Verhaeghe scored twice in game four, including the overtime-winning goal for the Panthers, tying the series up 2–2 in a 3–2 triumph. In game five, Verhaeghe scored twice and assisted on the other three Panthers’ goals in Florida's three-goal comeback, taking the game 5–3 to lead the series 3–2. In game six,
Claude Giroux scored a goal and provided two assists and Verhaeghe scored the overtime goal in a 4–3 victory sending the Panthers to the second round for the first time in 26 years.
(A2) Toronto Maple Leafs vs. (A3) Tampa Bay Lightning The Toronto Maple Leafs finished second in the Atlantic Division, earning 115 points. The Tampa Bay Lightning earned 110 points to finish third in the Atlantic Division. This was the first playoff meeting between these two teams. These teams split their four-game regular season series. The Lightning defeated the Maple Leafs in seven games. In game one, Maple Leaf's forward
Auston Matthews provided two goals and an assist in
Jack Campbell's 24-save 5–0 shutout.
Victor Hedman had a goal and three assists for the Lightning in game two, giving Tampa Bay a 5–3 victory. In game three,
Pierre Engvall provided three assists for the Maple Leafs, staving off a potential comeback from Tampa Bay and winning 5–2. In game four, the Lightning got off to a quick start, scoring three goals within the first eight minutes of the game en route to a 7–3 victory. The Maple Leafs came back from a 2–0 deficit in Game 5 with
William Nylander providing a goal and two assists in a 4–3 victory. In game 6, although the Maple Leafs came back from a two-goal deficit, the Lightning's
Brayden Point scored in overtime to extend the series to a seventh game in a 4–3 affair. In game 7,
Nick Paul scored twice while the Lightning defended their 2–1 lead onto the victory and a second round advancement. With their game seven loss, the Maple Leafs lost eight consecutive playoff series and ten potential series-clinching games. After Florida won a playoff series for the first time since
1996, Toronto held the NHL's longest active playoff series win drought, as they last won a playoff series in
2004.
(M1) Carolina Hurricanes vs. (WC1) Boston Bruins The Carolina Hurricanes finished first in the Metropolitan Division earning 116 points. Boston finished as the Eastern Conference's first wild card earning 107 points. This was the seventh playoff meeting between these two teams, with Boston winning five of the six previous series. They last met in the
2020 Eastern Conference first round, which Boston won in five games. Carolina won all three games in this year's regular season series. The Hurricanes defeated the Bruins in seven games, with the home team victorious in every game.
Antti Raanta made 35 saves in game one, backstopping the Hurricanes in a 5–1 victory. Upon Hurricanes forward
Nino Niederreiter's two goals and
Pyotr Kochetkov's 30 saves in relief of Raanta in game two, Carolina gained 2–0 series lead by defeating Boston 5–2. In game three,
Brad Marchand scored a goal and provided two assists in the Bruins' 4–2 victory. In game four, Marchand scored or provided an assist on every Bruins goal in Boston's 5–2 victory, tying the series 2–2. In game five,
Seth Jarvis scored twice and
Teuvo Teravainen assisted thrice in the Hurricanes 5–1 victory, taking a 3–2 series lead in the process. In game six,
Charlie Coyle and Marchand each scored a goal and provided an assist in the Bruins' 5–2 victory tying the series 3–3.
Max Domi scored twice and added an assist in game seven, granting Carolina a 3–2 victory and an advancement to the second round.
(M2) New York Rangers vs. (M3) Pittsburgh Penguins The New York Rangers finished second in the Metropolitan Division with 110 points. The Pittsburgh Penguins earned 103 points to finish third in the Metropolitan Division. This was the eighth playoff meeting between these two teams with Pittsburgh winning five of the seven previous series. They last met in the
2016 Eastern Conference first round, which Pittsburgh won in five games. New York won three of the four games in this year's regular season series. The Rangers
came back from a 3–1 series deficit to defeat the Penguins in seven games. In game one, although
Igor Shesterkin made 79 saves for the Rangers, Penguins forward
Evgeni Malkin scored for Pittsburgh at 5:58 of triple overtime to win 4–3. In game two,
Artemi Panarin and
Frank Vatrano both scored a goal and provided two assists in the Rangers' 5–2 victory. In game three, although the Rangers tied the game after being down 4–1, Penguins forward
Danton Heinen's goal proved to be the game-winning goal at 11:02 of the third period giving Pittsburgh a 7–4 victory. The Penguins scored five times in the second period of game four, chasing goalie Shesterkin in a 7–2 rout. In game five, the Rangers successfully came back from a two-goal deficit to win 5–3, forcing a sixth game.
Chris Kreider gave the Rangers a lead late in the third period of game six, giving his team a 5–3 victory and tying the series 3–3. In game seven and the subsequent overtime, Panarin scored for New York sending the Rangers to the second round with a 4–3 victory. This marked the first time the Penguins lost a game seven on the road in franchise history after winning the previous six instances. The Rangers equalled both the
Montreal Canadiens and
Vancouver Canucks for most comebacks from a 3–1 series deficit with three. The Rangers also became the first team in Stanley Cup playoff history to record three consecutive comeback wins in elimination games within the same series.
Western Conference first round (C1) Colorado Avalanche vs. (WC2) Nashville Predators The Colorado Avalanche finished first in the Central Division and Western Conference earning 119 points. The Nashville Predators earned 97 points to finish as the Western Conference's second wild card. This was the second playoff meeting between these two teams. Their only previous meeting was in the
2018 Western Conference first round, which Nashville won in six games. Nashville won three of the four games in this year's regular season series. The Avalanche defeated the Predators in a four-game sweep. Colorado scored five times in the first period of game one, forcing Nashville to switch goalies in a 7–2 affair. In game two, the Avalanche shot 51 times at Predators' goalie
Connor Ingram and at 8:31 of overtime,
Cale Makar scored to give Colorado a 2–1 victory.
Gabriel Landeskog scored and assisted twice in game three, helping the Avalanche obtain both a 7–3 victory and 3–0 series lead. In game four,
Andre Burakovsky's goal and two assists helped lift the Avalanche to a 5–3 victory, advancing to the second round.
(C2) Minnesota Wild vs. (C3) St. Louis Blues The Minnesota Wild finished second in the Central Division earning 113 points. The St. Louis Blues earned 109 points to finish third in the Central Division. This was the third playoff meeting between these teams with the teams splitting the two previous series. They last met in the
2017 Western Conference first round, which St. Louis won in five games. St. Louis won all three games in this year's regular season series. The Blues defeated the Wild in six games. In game one,
Ville Husso made 37 saves for the Blues and
David Perron scored a hat trick in St. Louis' 4–0 victory. The Wild returned with a hat trick of their own in game two when
Kirill Kaprizov scored Minnesota's first playoff hat trick in a 6–2 victory.
Marc-Andre Fleury made 29 saves for the Wild in game three, backstopping Minnesota into a 5–1 victory. Blues captain
Ryan O'Reilly scored a goal and two assists in game four, leading St. Louis to a 5–2 victory.
Vladimir Tarasenko scored a hat trick in game five spearheading his team to another 5–2 victory and a 3–2 series lead. In game six,
Jordan Binnington made 25 saves for the Blues, defeating the Wild 5–1 and advancing to the second round.
(P1) Calgary Flames vs. (WC1) Dallas Stars The Calgary Flames finished first in the Pacific Division earning 111 points. The Dallas Stars finished as the Western Conference's first wild card earning 98 points. This was the third playoff meeting between these two teams with Dallas winning both previous series. They last met in the
2020 Western Conference first round, which Dallas won in six games. Calgary won two of the three games in this year's regular season series. The Flames defeated the Stars in seven games. In game one, Calgary's defence limited the Stars' offence to 16 shots as goalie
Jacob Markstrom claimed a 1–0 victory. The Stars responded with their own shutout victory in game two, scoring twice in a 2–0 affair with
Jake Oettinger making 29 saves in the process.
Joe Pavelski led the Stars with two goals in game three, giving Dallas a 4–2 victory and a 2–1 series lead. The Flames put 54 shots on the Stars goaltender, and with four shots turning into goals, Calgary won game four, 4–1. In game five,
Mikael Backlund and
Andrew Mangiapane each scored a goal and provided an assist in Calgary's 3–1 comeback victory. In game six, Oettinger made 36 saves for the Stars leading his team to a 4–2 victory and forcing a seventh game. The Flames put on 67 shots in game seven, but with two finding the back of the net on both sides, the game went into overtime. In the extra period, Calgary forward
Johnny Gaudreau scored to give the Flames a 3–2 victory and a second round advancement. In the loss, Oettinger became the second goalie since 1955 to post 60 or more saves in a seventh game.
Mike Smith stopped all 30 shots in game two, ending his ten-game playoff losing streak with a 6–0 shutout victory. The Oilers dominated game three, forcing Los Angeles to switch goalies and giving
Evander Kane a hat trick in the process of an 8–2 rout.
Jonathan Quick claimed a 31-save shutout in game four, backstopping the Kings to a 4–0 victory. In the process, he became the leading United States-born goalie in playoff shutouts with 10. In game five, the Oilers came back from a two-goal deficit to tie the contest; however Kings forward
Adrian Kempe's overtime goal, his second score of the affair, gave Los Angeles the 5–4 victory and a 3–2 series lead. In game six,
Connor McDavid scored a goal and provided two assists in the Oilers' 4–2 victory, forcing a seventh game in Edmonton. In game seven, McDavid scored and assisted in a 2–0 victory as they advanced to the second round. ==Second round==