Main • Jacob Luke "Jake" Long (voiced by
Dante Basco): A Chinese-American 13-year-old (14 years old in the second season) who is half-human, half-dragon. He is the titular American Dragon. His personality is that of a cool, laid-back skateboarder who talks in rapper slang. He has a keen awareness of the newest developments and styles, is self-assured, and likes video games, extreme sports, all sorts of music, and the occasional comic book. He had a crush on pretty blonde schoolmate Rose until he found out she was actually the Huntsgirl, but their dual identities are bound to stir up trouble. After numerous trials and tribulations over the course of the series, Jake and Rose finally get together in the final episode. A running gag involves the mention of his embarrassing secrets, like having a teddy bear collection and sleeping with a nightlight, to blemish his reputation. His dragon abilities include flight, fire breath, a prehensile tail, and sharp claws, along with highly strong senses. • Luong Lao Shi (voiced by
Keone Young): Jake's maternal grandfather, who was formerly the Chinese Dragon. He runs an electronic shop on
Canal Street with the slogan "Never have a customer, never have a sale" alongside his only friend, Fu Dog. His attempts at training Jake sometimes do more damage (to Jake's brain) than help. His name is a reference to the Chinese word for "teacher". In his youth in 1972, before his first encounter with the Dark Dragon, Jake's grandpa was known as Lucky Lao Shi. • Fu Dog (voiced by
John DiMaggio): A 600-year-old
Shar-Pei and Lao Shi's only companion. Throughout his entire life, he and a hairless talking cat have fought over Fu's family amulet (causing famous disasters along the way). He is more "hip" than Lao Shi. • Arthur P. "Spud" Spudinski (voiced by
Charlie Finn): Jake's best friend, who is extremely loyal and somewhat slow, but he comes up with intelligent things to say at random times. He also has the entire works of Shakespeare committed to memory. There is a chance that Spud is half-wizard (this is hinted at when his grandfather happens to know the magic word to seal a Djinn back into a goblet). In Season 2, he gains a crush on the head cheerleader, Stacey, who hates him until they start dating near the end of the season. • Trixie Carter (voiced by Kittie Kaboom): Jake's other best friend, who is just as cool as he is. A witty, blunt, and sharp-tongued girl, a hardcore fashionista, but also the most logical and mature of the group. • Haley Kay Long (voiced by
Amy Bruckner): Jake's seven-year-old, intelligent, talented, overachieving, but annoying baby sister who also has dragon powers. She takes pride in her ability to expose all of Jake's secrets and highlight her own. Despite all of that, she admires Jake's bravery, selflessness, and ability as the American Dragon and sees him as a role model. It is hinted multiple times in the show that all her effort to be better than her brother is so she can impress him and get him to think of her as an equal. She knows that Jake would do anything for her, including forgetting all the problems she has ever caused between them, if it meant her safety. She wants to talk and hang out with him more. • Susan Long (née Luong) (voiced by
Lauren Tom): Jake and Haley's mother does not possess any natural dragon abilities like her family and children, having skipped her generation. She does all she can to keep her human husband, Jonathan, from discovering the existence of magic and her family being magical creatures. • Jonathan Long (voiced by
Jeff Bennett): Jake and Haley's mortal father, and a businessman originally from the Midwest, who is unaware that he is married into a family of dragons. In the series finale, he is initially shocked at his wife's family secret, but later comes to welcome it as he always knew there was something magical about them. • Rose/Huntsgirl (voiced by
Mae Whitman): Jake's love interest (later girlfriend in the series finale) and a natural dragon slayer known as the Huntsgirl, a member of the Huntsclan that slays magical creatures, especially dragons. She was born with a red birthmark on her arm resembling a Chinese dragon, leading the Huntsclan to kidnap her from her parents. She also has an identical twin sister whose fate is unknown. • Professor Hans Rotwood (voiced by
Paul Rugg): Jake's middle-aged German schoolteacher with an obsessive interest in magical creatures, and a quest to discover the American Dragon's identity (oblivious to the fact that it is Jake). Rotwood styles himself as an expert on mythical creatures, but his knowledge is superficial and his expertise a fraud.
Main villains • The Huntsman (voiced by
Jeff Bennett): The leader of the Huntsclan, a society of thieves that hunt and steal magical creatures for profit. They are highly trained and use sophisticated weapons. Huntsclan members have a specific birthmark that resembles a dragon. His true name and face were never shown. The Huntsman is #4 of the 13 threats to the magic community. In the second season, his outfit is redesigned as magenta and he sports a ninja mask and a dragon skull helmet. His face is finally revealed when his helmet is destroyed, and is ultimately killed by his protegee, Rose. • The Dark Dragon (voiced by
Clancy Brown): The secondary main
antagonist of the show. Considered the #1 threat to the magical world, the Dark Dragon hates all of humanity and intends to overthrow them. • Bananas B (voiced by
Dee Bradley Baker): A monkey with a rapper style and Jake's temporary animal guardian who later betrayed him to become Councilor Chang's assistant. He talks with an
Australian accent. • Councilor Chang (voiced by
Lauren Tom): A former member of the Dragon Council and the Dark Dragon's assistant who worked with Lao Shi when he first fought the Dark Dragon. • Eli Excelsior Pandarus (voiced by
Jonathan Freeman): A dark wizard who tries to be the world's most powerful sorcerer.
Recurring and guest • Sun Park (voiced by
Sandra Oh): Jake's home-ec schoolteacher, Haley's dragon mentor, and formerly the Korean Dragon. • Nigel Thrall (voiced by
Adam Wylie): An exchange student from
England who hides his identity as a wizard. He shared a temporal rivalry with Jake when they both ran for school president, but ended up defeating Maximius together. • Fred Nerk (voiced by Adam Wylie): The Australian Dragon who was Jake's temporary rival at the Dragon Council Games until he saved him from the Dark Dragon. • Jasmine (voiced by
Lacey Chabert): Jake's first date, who turned out to be a soul-sucking creature called a Nix. • Huntsboy #88 and Huntsboy #89 (voiced by
Kyle Massey and
Nicholas Brendon): Two of the Huntsman's new apprentices, supposedly both cousins of Rose. 88 is as hip-hop and arrogant as Jake, which ironically shows Jake how annoying he can really be, while 89 is more of a nerd. Neither knows how to fight, and they were only accepted into the Huntsclan due to killing monsters in video games. • Brad Morton (voiced by Matt Nolan): A 15-year-old jock bully at Jake's school who likes to make fun of him and frequently hits on Rose. • Sigmund Brock (voiced by
Corey Burton): Rotwood's former mentor who inspired him to research magical creatures. He is brought in to replace Rotwood as Principal of Fillmore Middle School when Jake gets Rotwood fired, but takes it upon himself to discover the dragon's identity, causing Rotwood to team up with Jake and get him fired. • Stacey Wintergrin (voiced by
Tara Strong): The school's cheerleader captain who is Spud's unrequited love interest until she eventually warms up to him. • Kara Oracle (voiced by Tara Strong): Sara's oracle twin sister is always in a bad mood, although she can only predict good things. • Sara Oracle (voiced by Tara Strong): Kara's oracle twin sister is always happy, although she can only predict bad things. • Veronica (voiced by Tara Strong): A half-human with eight spider legs who works at the Magus Bazaar. • Bertha the Giant (voiced by Tara Strong): A dim-witted female giant with a stinky foot. • Silver (voiced by
Kari Wahlgren): A
mermaid who is afraid of water and a medical science prodigy. • Ms. Dolores Derceto voiced by (
Susanne Blakeslee): is an undercover mermaid detective working as the principal of Jake's junior high who has a temporary romance with Lao Shi. • Danika Hunnicutt (voiced by
Jessica DiCicco): Jake's second love interest after Rose went to
Hong Kong , and is the school's swim team captain. She gets mad and leaves him after he accuses her of being the siren. She later became Jake's graduation partner. • Hank Carter (voiced by
Phil Morris): Trixie's father, who is a US Navy officer. • Olivia Mears (voiced by
Liliana Mumy): Haley's academic rival. • Yan Yan (voiced by
Tia Carrere): A Sphynx cat, also known as a Chinese Hairless, who has been fighting with Fu Dog over his family's amulet for centuries. She pretends to belong to a young girl called Olivia. • Huntsgirl #18 (voiced by Tara Strong): A student at the Huntsclan Academy who develops a crush on an undercover Spud due to his in-depth knowledge about dragons and fights over him with another student. ==Voice cast==