Symptoms of exposure to this compound include: • allergic reactions • strong
spasmolytic effect on smooth muscle of peripheral blood vessels • irritability •
palsy • copious sweating • dilated pupils • sharp drop then rise in body temperature •
dysuria •
dyspnea •
anxiety •
rectal tenesmus • urinary frequency • intermittent fever • fatty infiltration of the liver • heart muscle degeneration • death due to circulatory failure following
cardiovascular collapse Agranulocytosis often occurs. Ingestion may cause central nervous system stimulation, vomiting, convulsions,
cyanosis,
tinnitus,
leukopenia, kidney damage and coma. Ingestion may also lead to nausea, mental disturbances,
methemoglobinemia, chocolate-colored blood, dizziness, epigastric pain, difficulty in hearing, thready pulse and liver damage. Other symptoms reported via ingestion include
hemolytic anemia,
porphyria and severe gastrointestinal bleeding.
Bone marrow depression also occurs. Rare eye effects include
acute transient myopia. Chronic symptoms include: •
anorexia •
edema •
oliguria •
urticaria • hypersensitivity •
aplastic anemia • sore throat • fever • pharyngeal membrane • jaundice enlargement of the liver and spleen •
exfoliative dermatitis • gastric or duodenal erosion with perforation or bleeding • adrenal
necrosis •
thrombocytopenic purpura • acute
leukemia When heated to decomposition this compound emits toxic fumes of
nitrogen oxides. == Metabolism ==