From 1989 to 1992, Magnuson played Catherine Hughes, the comically hip editor-in-chief of a Chicago magazine in the television
sitcom Anything But Love, opposite
Jamie Lee Curtis and comedian
Richard Lewis, and played a liberal political commentator on comedian
Wanda Sykes' 2003
Fox sitcom
Wanda at Large. Magnuson's film roles have included a snarly real estate agent in
Panic Room, Alan's mother in
Small Soldiers, a madam in
Tank Girl, Mel Gibson's "money junkie" ex-wife in
Tequila Sunrise,
Tom Berenger's estranged but horny ex-girlfriend in
Love at Large, a secretary in
Clear and Present Danger, and a sexy victim of
David Bowie's vampire in
The Hunger. Her TV guest appearances include an episode each of the
Lifetime cable-network
fiction-suspense anthology
The Hidden Room; the cult-hit,
surrealistic comedy-drama
The Adventures of Pete and Pete and
Salute Your Shorts on
Nickelodeon; the sitcoms
The John Larroquette Show,
The Drew Carey Show,
Caroline in the City, and
Frasier; and the
police procedural drama
CSI: Miami. In the 1996 telefilm ''
The Munsters' Scary Little Christmas'' She appeared in the 1990
Redd Kross music video for the song "Annie's Gone", written about her. As writer Jason Anderson summarized her work through 1996, "She's been appearing in various states of undress for artistic purposes since her performance art daze in late-'70s New York [where s]he was indie rock's thinking vixen...." In 1997 she provided guest vocals for the band
Tindersticks on the song "Buried Bones" from their album
"Curtains". In 2003, Magnuson began touring a one-woman stage show,
Pretty Songs & Ugly Stories, which she mounted through at least July 2006. She played Sister Elizabeth Donderstock in the play
The Book of Liz, written by
Amy Sedaris and
David Sedaris, in May 2005 at the 2nd Stage Theatre in
Hollywood, California. Other theater work has included playwright
John Patrick Shanley's
Four Dogs and a Bone at the
Lucille Lortel Theater in New York City, the one-woman shows
You Could Be Home Now (which opened the 1990 Serious Fun festival at New York City's
Lincoln Center), and
Rave Mom (opened in New York City October 2001), and in a neo-
burlesque show,
The Velvet Hammer. A
Village Voice review described the autobiographical
Rave Mom as Magnuson's "travels through 1999 — a year of
ecstasy-popping, bad romance-chasing and searching for escapism and meaning after her brother's death from AIDS. Magnuson has a thoroughly charming presence [but] her stories of celebrity-studded Oscar parties, kid-filled raves, a wealthy dotcom suitor, and so on, come off as utterly self-absorbed and trivial..." She has performed at the
Revlon/
UCLA Breast Center benefit series
What A Pair! in 2005, performing with
Elaine Hendrix "Tips" from the musical
Pump Boys & Dinettes, and 2006, performing with
Samantha Shelton. She appeared in ''What's My Line? Live on Stage'' in Los Angeles on Sept 14, 2006. For eight years, Magnuson wrote a monthly column, "LA Woman", in the magazine
Paper, as well as an accompanying blog. In late 2006, Magnuson released her second solo album,
Pretty Songs & Ugly Stories. It was produced and co-written by long-time musical director and accompanist
Kristian Hoffman, with whom Magnuson had had a creative relationship since meeting him while directing "The New Wave Vaudeville Show" in 1976. In 2007 and 2008, Magnuson performed in a cabaret act,
Dueling Harps, with Adam Dugas,
Mia Theodoratus, and Alexander Rannie. In 2009, Magnuson created a one-woman performance piece,
Back Home Again (Dreaming Of Charleston), that was commissioned by
Charleston, West Virginia's FestivAll. In 2018, Magnuson joined the cast of
The Man in the High Castle, for five episodes, as Caroline Abendsen, the wife of the title character Hawthorne Abendsen, played by
Stephen Root. Magnuson appeared in the first season of
Star Trek: Picard as Fleet Admiral Kirsten Clancy, the commander-in-chief of
Starfleet. Magnuson participated in a staged conversation about
Keith Haring with
Steven Reigns at
The Broad for World AIDS Day 2022. ==Personal life==