Main cast •
Michael Jai White as Black Dynamite,
Jim Kelly • Byron Keith Minns as Bullhorn,
Lionhorn,
Rudy Ray Moore, Singer,
Tuskegee Airman •
Kym Whitley as Honeybee,
Tinbee, Old Lady •
Tommy Davidson as Cream Corn,
Scarehorn, The Boss Man, Red Light
Additional voices •
Carlos Alazraqui as Helicopter Pilot •
Tichina Arnold as Tinbee's Singing Voice •
Erykah Badu as Fatback Taffy, Fat Hoe Crow,
Rita Marley, Wolf •
Eric Bauza as The Fiendish Dr. Wu, Chinatown Assassin, R.A.C.I.S.T.,
Sidney Poitier,
Dick Clark, Newscaster, Child, Reporter • Liz Benoit as Foxxy Mama •
Tae Brooks as
Michael Jackson •
Corey Burton as Dennis Flynn,
Fred Rogers,
Phil Drummond •
Chance the Rapper as
Bob Marley •
Michael Colyar as Sweet Butter •
Affion Crockett as
Joe Jackson •
DeRay Davis as Ninja,
Isaac Layes, Ringo Mandingo •
John DiMaggio as
Rip Tayles, Female Cop,
J. Edgar Hoover, Rump Rangers Human Horse, Various Gay People •
Godfrey as
Al Sharpton •
David Alan Grier as The Doctor •
Eddie Griffin as
Richard Pryor,
Paul Mooney •
Arsenio Hall as Tasty Freeze •
Samuel L. Jackson as Captain Quinton • Carl Jones as Frank the John, Crenshaw Pete, Puppet Minion, Shark Victim, Stuey Fig Newton, Reverse Strip Club Announcer, The Mayor of Beach City, Teacher, Laughing Prisoner,
James Brown,
Thick James •
Orlando Jones as Basehead, Flying Junkie, Stuey's Brother • Rochelle Jordan as
Cindy Breakspeare •
Sean Kingston as Dexter, Saint •
Jonathan Kite as
Richard Nixon,
Henry Kissinger,
James Bonds (
Sean Connery and
Roger Moore), News Reporter,
Elvis Presley •
Phil LaMarr as
Muhammad Ali •
Lil' Mo as Offscreen Nurse, Horse Carriage Woman, Teacher, Rondell's Mom •
Luenell as
Moms Mabley •
Mel B as Connie Lingus • Hugh Moore as Lamont •
Charlie Murphy as Another Cat Named Rallo, Another Slave Cat Named Rallo •
Tim Blake Nelson as Chief Humphrey Magillahorn,
The Wicked Bitch of the West Side,
Donald Sterling, Television Executive, Cracker Cop, Adult Film Director • Georgette Perna as Kids •
Clifton Powell as Crenshaw the Slime, Daddy Dynamite •
Donnell Rawlings as A Cat Named Rallo, A Slave Cat Named Rallo •
Christopher "Kid" Reid as John the John,
Sun Tzu, Black Leprechaun, Jamaica Labour Party Member •
Kevin Michael Richardson as
Melvin Van Peebles,
Don Cornelius,
Bill Cosby,
Fred Berry •
Eddie Rouse as
Spike Lee •
J. B. Smoove as That Frog Kurtis, That Bastard Kurtis, the Frogs of Incense •
Snoop Dogg as Leroy Van Nuys •
Aries Spears as
Mr. T,
O. J. Simpson •
Cree Summer as
Li'l Orphan Willis • Tiffany Thomas as Li'l Orphan TerRio •
Greg Travis as
Ku Klux Klan Grand Wizard •
Tyler, the Creator as
Broto •
Waka Flocka Flame as Waka Blocka Blaow • Jason Walden as Dennis Flynn •
Tionne "T-Boz" Watkins as
Pam Grier, Reverse Stripper •
Billy West as MASA Scientist •
Denzel Whitaker as Donald the Accountant,
Jermaine Jackson •
Dennis L. A. White as Arnold's Stomach •
Gary Anthony Williams as George Washington Carver III, Radio DJ, Reporter,
Howard Cosell •
Debra Wilson as Amazon Moon Bitch Leader, Lil' Orphan Penny,
Eartha K.I.T.T., Euphoria,
Li'l Orphan Arnold, Li'l Orphan Dudley
Li'l Orphan Rodney King, Li'l Rodney
Munchkins, Givinya Morehead, Child Services Lady, Hotel Employee, Hoe Crows •
Cedric Yarbrough as Chocolate Giddy-Up ==Episodes==