In a stretch of woods, two hunters are caught in a thunderstorm. They decide to seek refuge in Willows House, supposedly abandoned and
haunted. They find Willows House occupied, and the current owner, scientist Dr. Eric Vornoff, denies them hospitality. They attempt to force their entry into the house, but a giant octopus is released from its tank and sent after them. The octopus kills one of the hunters while Vornoff's mute assistant Lobo captures the other. Vornoff experiments on the unwilling hunter, who dies on the operating table. There are now twelve missing victims. Reporter Janet Lawton vows to go to Lake Marsh to investigate. Officer Tom Robbins and Lieutenant Dick Craig, Janet's
fiancé, talk to Professor Vladimir Strowski, an intellectual from Europe who agrees to assist in investigating the Marsh but not at night. That night, another storm begins. Janet drives alone to Lake Marsh, but visibility is poor, and she drives off the road and into a ravine. Lobo rescues her. Janet awakens to find herself a prisoner of Vornoff, who uses
hypnosis to put her back to sleep. The following day, Craig and Robbins drive to the area around Lake Marsh, a swamp. The partners discuss the strange weather and mention that the newspapers could be right about "the atom bomb explosions distorting the atmosphere". The duo eventually discovers Janet's abandoned car; she becomes the thirteenth missing victim. They leave the swamp while Strowski drives a rented car to the swamp. Janet awakens at Willows House. Vornoff assures her that Lobo is harmless, but the giant seems fascinated with Janet. Lobo is human, and Vornoff found him in the "wilderness of
Tibet". Vornoff hypnotically places Janet back to sleep. He orders Lobo to transport her to Vornoff's private quarters. Meanwhile, Strowski approaches Willows House and enters through the unlocked front door. While Strowski searches the house, Vornoff arrives to greet him. Their country of origin is interested in Vornoff's experiments with
atomic energy and wants to recruit him. Two decades prior, Vornoff had suggested using experiments with
nuclear power, which could create
superhumans of great strength and size. In response, he was branded a
madman and exiled by his country. Strowski dreams of conquest in their country's name, while Vornoff dreams of his creations conquering in his own name. Strowski is then attacked and forced into a cage, where the octopus kills him. Meanwhile, Craig and Robbins return to the swamp and discover Strowski's abandoned car. The partners split up to search the area, Craig heading towards Willows House. In the secret laboratory, Vornoff uses a wave of his hand to
telepathically summon Janet to his current location. She arrives dressed as a bride. Vornoff has decided to use her as the next subject of his experiments. Lobo is reluctant to participate in this experiment, and Vornoff uses a whip to re-assert his control over him. Meanwhile, Craig enters the house and accidentally discovers a secret passage. He is himself captured by Vornoff and Lobo. As the experiment is about to begin, Lobo is distressed. He decides to rebel and knocks Vornoff out. Lobo then releases Janet and transports the unconscious Vornoff to the operating table. Vornoff becomes the subject of his own human experiment. This time the experiment works and Vornoff transforms into an atomic-powered superhuman being. He and Lobo physically struggle, and their fight destroys the laboratory and starts a fire. Lobo is electrocuted when Vornoff shoves him into a control panel. Vornoff grabs Janet and escapes from the flames. Robbins and other officers arrive to help Craig. The police pursue Vornoff through the woods. There is another thunderstorm, and a lightning strike further destroys Willows House. With his home and equipment destroyed, a distressed Vornoff abandons Janet and attempts to escape. Craig rolls a rock at him and lands him in the water with the octopus. They struggle until a nuclear explosion obliterates both combatants. Apparently, the end result of the chain reaction started at the destroyed laboratory. Robbins says of Vornoff "he tampered in God's domain". ==Cast==