Brice found his break into both the business and political worlds under unusual circumstances. Around 1880, with his law practice proving unsuccessful and his mother's home at risk of foreclosure, Brice offered to attend to any legal interests with which the mortgage lender needed help. The lender, then-Governor
Charles Foster, declined the legal help but offered to pay Brice five hundred dollars to negotiate a business deal with
Wall Street on his behalf. Brice accepted and proved a shrewd businessman; Ignoring Foster's explicit instructions for his work on the business proceedings in New York and instead following his instincts, Brice returned with a shocking profit of $40,000 and earned the trust and friendship of the Governor. With Foster's support, Brice guided the railroad through the
Panic of 1873 and expanded it into
Lima and the surrounding region. His most notable achievement was perhaps his role in the 1882 construction of the
Nickel Plate Road which ran from New York to St. Louis. He later sold this road for a generous profit to
William Henry Vanderbilt, who recognized it as a dangerous competitor. Brice rose to President of the company in 1887, which by then was known as the
Lake Erie and Western Railroad. Over time, Brice netted a great fortune, laying claim to ten different railroads while spreading into numerous other businesses, including the National Telegraph Company and the Chase National Bank of New York. Later in life, Brice became involved with railroad projects in
China. He was a founding member of the American Asiatic Association, an organization responsible for pursuing American trade interests in China under the
Open Door Policy. In the late 1890s, he began an attempt to build a railroad between
Canton and
Hankou on mainland China, but he died before the project was completed. Throughout his career, Brice remained selfless in his aims and frugal in his desires, unlike most of the so-called
robber barons of his day. According to historian James White, Brice did not accept much compensation for his services during a business transaction and often held himself accountable to the public by "stripping a proposition of every incumbrance and laying it bare for inspection." ==Political career==