In the spring of 1329, Cangrande succeeded in obtaining the title of Imperial Vicar of
Mantua from the
Emperor, intending to move against the ruling
Gonzaga family in that city. These plans were put on hold however as a change of government at
Treviso had produced a number of powerful exiles willing to help him conquer the city in exchange for their reinstatement. On 2 July 1329, Cangrande left
Verona for the last time and within a few days his large army was laying siege to Treviso. Quickly running low on supplies and bereft of external help, the city's overlord Guecello Tempesta surrendered the city to Cangrande. On 18 July, Cangrande made his state entry to Treviso, the crowning moment in his long struggle to subdue the cities of the
Trevisan Mark. However, his triumph was marred, for he had become seriously ill as the result, according to contemporary accounts, of drinking from a polluted spring a few days before. As soon as he arrived at his lodgings he took to his bed and on the morning of 22 July 1329, after settling his affairs as best he could, he died. Cangrande's body was taken out of Treviso at nightfall and drawn on a bier to Verona where it was escorted by the nobles into the city preceded by twelve knights, one of whom wore Cangrande's armour and carried his unsheathed sword. The body was temporarily housed in the church of Santa Maria Antiqua, then appears to have been moved twice, once to a marble tomb in the churchyard (previously believed to be that of Cangrande's father
Alberto I della Scala) and finally to the
marble tomb over the church entrance, topped with an impressive equestrian statue of a smiling Cangrande in tournament attire (the latter now in the Museum of
Castelvecchio). As he had no legitimate sons, his titles passed to his nephews, Mastino and Alberto della Scala.
Modern postmortem In February 2004, Cangrande's body was removed from its sarcophagus for scientific tests, one of the objectives being to see whether the cause of his death could be ascertained. The body was found to be naturally mummified and in an exceptionally good state of preservation, so much so that some of his internal organs could be examined. It transpired the actual cause of death was poisoning from lethal amounts of the drug
digitalis, extracted from one of the "foxglove" family of plants. The evidence leans towards deliberate murder by poisoning, perhaps under the guise of medical treatment for the illness Cangrande is said to have contracted from drinking infected spring water prior to his arrival in
Treviso. A physician of Cangrande's was hanged by his successor Mastino II, adding more weight to the possibility of foul play having been at least suspected, although who was ultimately behind the killing is likely to remain a mystery. One of the principal suspects (at least in terms of motive) was Cangrande's nephew, the ambitious Mastino II himself. Furthermore, according to the DNA examination carried out in 2021, Cangrande also suffered from a
genetic metabolic myopathy, the
Pompe disease. == Legacy ==