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Ruta graveolens

Ruta graveolens, commonly known as rue, common rue, ruda, arruda or herb-of-grace, is a species of the genus Ruta grown as an ornamental plant and herb. It is native to the Mediterranean. It is grown throughout the world in gardens, especially for its bluish leaves, and sometimes for its tolerance of hot and dry soil conditions. It is also cultivated as a culinary herb, and to a lesser extent as an insect repellent and incense.

Etymology
The specific epithet graveolens refers to the strong-smelling leaves. == Description ==
Description
Rue is a woody, perennial shrub. Its leaves are oblong, blue green and arranged bipinnately with rounded leaflets; they release a strong aroma when they are bruised. The flowers are small with 4 to 5 dull yellow petals in cymes. The first flower in each cyme is pentamerous (five sepals, five petals, five stamens and five carpels. All the others are tetramerous (four of each part). They bear brown seed capsules when pollinated. == Uses ==
Uses
Traditional use In the ancient Roman world, the naturalists Pedanius Dioscorides and Pliny the Elder recommended that rue be combined with the poisonous shrub oleander to be drunk as an antidote to venomous snake bites. The refined oil of rue is an emmenagogue and was cited by the Roman historian Pliny the Elder and Soranus as an abortifacient (inducing abortion). Culinary use Rue has a culinary use, but since it is bitter and gastric discomfort may be experienced by some individuals, it is used sparingly. Although used more extensively as a culinary herb in former times, it is not typically found in modern cuisine. Due to small amounts of toxins it contains, it must be used in small amounts, and should be avoided by pregnant women or people who have liver issues. It has a variety of other culinary uses: • It was used extensively in ancient Near Eastern and Roman cuisine (according to Ibn Sayyar al-Warraq and Apicius). • Rue is used as a traditional flavouring in Greece and other Mediterranean countries. • Used in Old World beers as flavouring ingredient. • The rue that is widespread in Ethiopian culture is a different species, R. chalapensis. Other Rue is also grown as an ornamental plant, both as a low hedge and so the leaves can be used in nosegays. Most cats dislike the smell of it, and it can, therefore, be used as a deterrent to them (see also Plectranthus caninus). Caterpillars of some subspecies of the butterfly Papilio machaon feed on rue, as well as other plants. The caterpillars of Papilio xuthus also feed readily on it. It finds many household uses around the world as well. It is traditionally used in Central Asia as an insect repellent and room deodorizer. In premodern East Asia, bookmarks were made from rue in order to drive away bookworms and insects. === Purported use against evil === In Brazil, the Ruta plant, known locally as arruda, is believed to possess protective qualities against malevolent forces, particularly the evil eye. The same tradition exists among Sephardic Jews, who will often place it near vulnerable individuals, such as newborns, children, and mothers, to ward off evil. Among Sephardic Jews, beyond its symbolic significance, ruda is valued for its medicinal properties. When combined with sugar, it is traditionally used to soothe eye discomfort and alleviate the symptoms of a mild cold. Additionally, inhaling ruda is thought to mitigate the effects of shock. Ruda's significance in Sephardic Jewish culture also extends to religious practices. During Yom Kippur, a Jewish holiday marked by fasting, Sephardic synagogues often pass ruda among congregants to revitalise them. Other Hasidim rely on the works of a famous Baghdadi Kabbalist Yaakov Chaim Sofer who makes mention of the plant "ruda" () as an effective device against both black magic and the evil eye. ==Toxicity==
Toxicity
Rue is generally safe if consumed in small amounts as a herb to flavor food. Rue extracts are mutagenic and hepatotoxic. Toxicity with large ingestions can cause multiorgan failure, significant electrolyte derangements and hemodynamic instability requiring hemodialysis. While the specific mechanism of toxicity isn't known, the coumarin-like chalepesin is suspected. Containing psoralen, a furanocoumarin that intercalates in the DNA of dermal cells, rue can cause photodermatitis of ultraviolet light-exposed skin. Thus exposure to common rue, or herbal preparations derived from it, can cause severe phytophotodermatitis, which results in burn-like blisters on the skin. The mechanism of action is currently unknown. == Chemistry ==
Chemistry
A series of furanoacridones and two acridone alkaloids (arborinine and evoxanthine) have been isolated from R. graveolens. It also contains coumarins and limonoids. Cell cultures produce the coumarins umbelliferone, scopoletin, psoralen, xanthotoxin, isopimpinellin, rutamarin and rutacultin, and the alkaloids skimmianine, kokusaginine, 6-methoxydictamnine and edulinine. The ethyl acetate extract of R. graveolens leaves yields two furanocoumarins, one quinoline alkaloid and four quinolone alkaloids including graveoline. The chloroform extracts of the root, stem and leaf shows the isolation of the furanocoumarin chalepensin. The essential oil of R. graveolens contains two main constituents, undecan-2-one (46.8%) and nonan-2-one (18.8%). ==Symbolism==
Symbolism
The bitter taste of its leaves led to rue being associated with the (etymologically unrelated) verb rue "to regret". Rue is well known for its symbolic meaning of regret and it has sometimes been called "herb-of-grace" in literary works. In mythology, the basilisk, whose breath could cause plants to wilt and stones to crack, had no effect on rue. Weasels who were bitten by the basilisk would retreat and eat rue in order to recover and return to fight. In the Bible Rue is mentioned in the New Testament, Luke 11:42: "But woe unto you, Pharisees! For ye tithe mint and rue and all manner of herbs". In Jewish culture Sephardic Jewish tradition has long valued ruda for its diverse applications in health, religious practices, and spiritual well-being. It was in the Ottoman Balkans, rather than Medieval Spain, that Sephardic Jews encountered ruda and adopted its associated traditions and beliefs. "Chervona Ruta" (Червона Рута—"Red Rue") is a song, written by Volodymyr Ivasyuk, a popular Ukrainian poet and composer. Pop singer Sofia Rotaru performed the song in 1971. In Germany Rue as heraldic charge (Crancelin) is used on the coats of arms of Saxony and Saxony-Anhalt. Until 1918 the King of Saxony have issued the Order of the Rue Crown, the highest order of the Kingdom of Saxony. In Shakespeare It is one of the flowers distributed by the mad Ophelia in William Shakespeare's Hamlet (IV.5): :"There's fennel for you, and columbines: :there's rue for you; and here's some for me: :we may call it herb-grace o' Sundays: :O you must wear your rue with a difference..." It is used by the clown Lavatch in ''All's Well That Ends Well'' (IV.5) to describe Helena and his regret at her apparent death: :"she was the sweet marjoram of the salad, or rather, the herb of grace." It was planted by the gardener in Richard II to mark the spot where the Queen wept upon hearing news of Richard's capture (III.4.104–105): :"Here did she fall a tear, here in this place :I'll set a bank of rue, sour herb of grace." It is also given by the rusticated Perdita to her disguised royal father-in-law on the occasion of a sheep-shearing (''Winter's Tale'', IV.4): :"For you there's rosemary and rue; these keep :Seeming and savour all the winter long." In other English literature It is used by Michael in Milton's Paradise Lost to give Adam clear sight (11.414): :"Then purg'd with euphrasy and rue :The visual nerve, for he had much to see." Rue is used by Gulliver in ''Gulliver's Travels'' (by Jonathan Swift) when he returns to England after living among the "Houyhnhnms". Gulliver can no longer stand the smell of the English Yahoos (people), so he stuffs rue or tobacco in his nose to block out the smell. "I was at last bold enough to walk the street in his (Don Pedro's) company, but kept my nose well with rue, or sometimes with tobacco". ==See also==
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