Several hypotheses have been put forward about the meaning of
The Creation of Adams highly original composition, many of them taking Michelangelo's well-documented expertise in
human anatomy as their starting point.
Depiction of the human brain In 1990 in
Anderson, Indiana,
physician Frank Meshberger noted in the
Journal of the American Medical Association that the background figures and shapes portrayed behind the figure of God appeared to be an anatomically accurate picture of the
human brain. On close examination, borders in the painting correlate with major
sulci of the
cerebrum in the inner and outer surface of the brain, the
brain stem, the
frontal lobe, the
basilar artery, the
pituitary gland and the
optic chiasm. In February 2026, I.A. Pireev published a study entitled "Michelangelo. The Brain. Biochemistry of Religions", in which the author substantiates a fundamentally different conceptual vision of Michelangelo's design, which is that the fresco reflects the human perception system based on the five basic senses and Aristotle's ”three-ventricle" theory (in the version described by Leonardo da Vinci - corresponding to the location of the
sens communis in the middle ventricle of the brain). To this end, Michelangelo singles out five Angels and artistically endows them with corresponding functions. As a result, the contours of God's left hand correspond to the middle ventricle of the brain. And the central Angel, on whom God leans, symbolizes the
sens communis. At the time the fresco was painted, aspects of the above theory were officially reflected in the works of Thomas Aquinas and in the doctrine of the Catholic Church. This work reinterprets the plot of the famous fresco, interpreting it as an anatomically accurate depiction of the process of the emergence of human intelligence and consciousness.
Depiction of the birth process Alternatively, it has been observed that the red cloth around God has the shape of a human
uterus (one art historian has called it a "uterine mantle") and that the scarf hanging out, coloured green, could be a newly cut
umbilical cord. In 2015 a group of Italian researchers published on
Mayo Clinic Proceedings an article where the images of the mantle and the postpartum uterus were overlapped. According to Enrico Bruschini (2004), "This is an interesting hypothesis that presents the Creation scene as an idealised representation of the physical birth of man ("The Creation"). It explains the
navel that appears on
Adam, which is at first perplexing because he was created, not born of a woman." Due to Michelangelo's in-depth knowledge of human anatomy, he insinuates that this rib outline is intentional, and represents the rib of
Eve. Campos suggests that this extra rib inclusion was a way for Michelangelo to represent Adam and Eve being created side by side, which differs from the
Catholic tradition that states Eve was created after Adam. There is significant evidence that Michelangelo radically disagreed with many Catholic traditions and had a tumultuous relationship with the commissioner of the ceiling,
Pope Julius II. Thus, Campos suggests that the rib inclusion was an intentional way to slight Pope Julius II and the Catholic Church, without having to admit fault, as very few people knew anything about human anatomy at the time and could challenge the piece. == Critical sketches ==