In January 1998, Rhys went to New Zealand to star in
Greenstone, a colonial costume drama for television. He then landed a role in
Titus, Julie Taymor's adaptation of
Titus Andronicus, starring
Anthony Hopkins and
Jessica Lange. Next he played Ray in
Peter Hewitt's comedy film
Whatever Happened to Harold Smith? After returning to Wales, he did two consecutive films with
Jonathan Pryce:
The Testimony of Taliesin Jones, a film about a dysfunctional single-parent family in which he played the elder son, and
Sara Sugarman's comedy
Very Annie Mary, in which he played the role of Nob. Rhys would later reunite with
Very Annie Mary star
Rachel Griffiths on
Brothers & Sisters. In 2000, Rhys played the lead role in
Metropolis, a drama series for
Granada TV about the lives of six twenty-somethings living in London. Next he starred in
Peaches, the film of the play written and directed by
Nick Grosso. Rhys starred as Benjamin in the 2000 world premiere of the stage adaptation of
The Graduate, alongside
Kathleen Turner at the
Gielgud Theatre in London's
West End. Rhys travelled to Ireland to star in the 18th-century swashbuckling adventure
The Abduction Club. He played the lead role of Darren Daniels in
Tabloid and then returned to New Zealand to shoot the epic drama
The Lost World for the BBC. His other film credits include the independent horror film
Deathwatch in
Prague and
Fakers, a comic crime caper. In 2003, he played Justin Price in the
final episode of the long-running television series
Columbo. He appeared in the independent feature
Love and Other Disasters, in
Virgin Territory, and as poet
Dylan Thomas in the love quadrangle biographical film
The Edge of Love. He moved to
Santa Monica after being cast in
ABC's show
Brothers & Sisters as gay lawyer
Kevin Walker. The show had a five-season run, coming to an end in 2011. The
Public Broadcasting Service (PBS) aired it in the United States as one feature-length episode on 15 April 2012. In 2012, Rhys reprised Sir
Alec Guinness's 1959 double role of John Barratt / Jacques DeGué in a new adaptation of
Daphne du Maurier's
The Scapegoat. That same year, Rhys was cast as Jimmy in the
Roundabout Theatre Company's
Off-Broadway revival of
John Osborne's play,
Look Back in Anger, at the
Laura Pels Theatre in the Harold and Miriam Steinberg Center for Theatre. The production played a limited engagement through 8 April 2012. In 2013, Rhys starred in the television adaptation of the
P. D. James novel
Death Comes to Pemberley as
Jane Austen hero
Fitzwilliam Darcy. He starred opposite
Keri Russell in the
FX series
The Americans, a 1980s
Cold War spy drama about Russian
KGB sleeper agents. The show debuted in January 2013, and aired its sixth and final season in 2018. Rhys received a
Primetime Emmy Award for his acting in the sixth season. In 2025, Rhys starred as one of the lead characters, Nile Jarvis, in Netflix's eight-part miniseries
The Beast in Me. From 16 to 28 November 2025, he returned to the Welsh stage to play
Richard Burton in the one-man play
Playing Burton, celebrating the 100th anniversary of Burton's birth and raising funds for the inaugural season of
Michael Sheen's new
Welsh National Theatre. He received positive reviews from critics for his performance as Burton. In 2026, Rhys voiced the character of Dinosaurus in the fourth season of
Invincible. ==Business ventures==