's character was the subject of the season's main mystery. The fifth season had thirteen roles receiving
star billing, with eleven out of twelve returning from
the previous season. The series is narrated by
Brenda Strong, who portrays the deceased
Mary Alice Young, as she observes from beyond the grave the lives of the
Wisteria Lane residents and her former best friends.
Teri Hatcher portrayed
Susan Mayer, now separated from Mike and in a relationship with her painter.
Felicity Huffman portrayed
Lynette Scavo, who deals with her now teenage sons.
Marcia Cross portrayed
Bree Hodge, who has become a successful business woman and author.
Eva Longoria portrayed
Gabrielle Solis, who has lost her money and beauty and now looks after a blind husband and two daughters.
Nicollette Sheridan portrayed
Edie Williams, who returns to Wisteria Lane with a new husband after leaving the neighborhood towards the end of the previous season.
Ricardo Antonio Chavira portrayed
Carlos Solis, Gabrielle's husband who is still blind but with a chance to recover his sight and his career as a business executive.
Doug Savant portrayed
Tom Scavo, Lynette's husband who is facing a mid-life crisis.
Kyle MacLachlan portrayed
Orson Hodge, Bree's husband who feels overshadowed by her success.
Dana Delany portrayed
Katherine Mayfair, Bree's business partner and Mike's new girlfriend.
James Denton portrayed
Mike Delfino, Susan's ex-husband and the target of a man who seeks revenge on him.
Shawn Pyfrom was promoted from an "also starring" credit to a formal "starring" credit playing
Andrew Van de Kamp, Bree's homosexual son who now works with her in her business. Also joining the principal cast was actor
Neal McDonough as
Dave Williams, whose mysterious arc is the season's main storyline.
Andrea Bowen departed from the principal cast but was credited as "special guest star" in the episode "
City on Fire" playing the role of
Julie Mayer, Susan's daughter, who is now attending college. The "also starring" cast had many changes. The roles of the Scavo children were recast in order to reflect their new ages following the time jump.
Charlie and
Max Carver replaced
Shane and Brent Kinsman as
Porter and Preston Scavo, respectively. The Kinsman twins appeared in a flashback in this episode. Joshua Logan Moore was cast as
Parker Scavo, a role previously played by
Zane Huett, and Kendall Applegate joined the cast as
Penny Scavo, who had previously been portrayed by several toddler actresses. Many established guest stars from previous seasons also returned.
Kathryn Joosten portrayed
Karen McCluskey, one of the most prominent residents of Wisteria Lane.
Richard Burgi portrayed
Karl Mayer, Susan's ex-husband and Bree's new divorce lawyer.
Tuc Watkins and
Kevin Rahm respectively played
Bob Hunter and Lee McDermott, a gay lawyer and his husband. Part of Susan's storyline were
Gale Harold appearing as
Jackson Braddock, a painter and Susan's new love interest, Mason Vale Cotton playing
M.J. Delfino, Susan and Mike's son, and
John Rubinstein portraying
Principal Hobson, headmaster at M.J.'s school. Part of Lynette's storyline were
Polly Bergen in the role of her mother
Stella Wingfield,
Gail O'Grady appearing as Anne Schilling, the mother of Porter's best friend who starts an affair with him, and
Peter Onorati portraying Warren Schilling, Anne's abusive husband and owner of a club that is burnt down. Part of Gabrielle's storyline were
Madison De La Garza and Daniella Baltodano respectively playing
Juanita and
Celia Solis, stepmother Gaby's troublesome daughters,
Jeff Doucette appearing as
Father Crowley, priest at the local Catholic church,
Frances Conroy portraying Virginia Hildebrand, a rich woman that hires Carlos to become her personal massage therapist,
David Starzyk playing Bradley Scott, Carlos's boss after he regains his sight,
Ion Overman portraying Maria Scott, Bradley's wife,
Megan Hilty acting as Shayla Grove, Bradley's mistress,
Lesley Boone in the role of Lucy Blackburn, Carlos's ex-girlfriend from college, and future series regular
Maiara Walsh, who appeared as Carlos's niece
Ana Solis in the season finale. Part of the main mystery arc were
Stephen Spinella portraying Dr. Samuel Heller, Dave's psychiatrist, and
Lily Tomlin playing Roberta Simonds, Mrs. McCluskey's sister who helps her to do some research on Dave. For the
100th episode of the series, many former cast members returned, including
Steven Culp as
Rex Van de Kamp, Bree's deceased first husband,
Christine Estabrook as
Martha Huber, the woman that blackmailed Mary Alice and was killed by Paul Young, and
Lucille Soong as Yao Lin, Gabrielle's former maid.
Beau Bridges made a special guest appearance as Eli Scruggs, Wisteria Lane's handyman who managed to help every one of the housewives in a different way. ==Episodes==