2012 NFL draft Entering the
NFL Combine as a potential first rounder, Poe impressed with an "epic workout performance" according to
ESPN's
Todd McShay, who afterwards projected him to go as high as No. 11 to the
Kansas City Chiefs. NFL.com draft analyst
Mike Mayock upgraded Poe from No. 3 to No. 1 in his defensive tackle positional ranking. Poe particularly impressed with a 4.98 sec 40-yard dash, despite at being the fifth-heaviest defensive linemen to weigh in at the NFL Combine since 2000—behind only
Terrence Cody, Ahmad Childress,
Frank Okam, and
Alameda Ta'amu. Additionally, he recorded 44 repetitions in the bench press, which tied
Brodrick Bunkley for fourth-most since 2000. Due to his raw athleticism, some in the media afterwards compared him to
All-Pro defensive lineman
Haloti Ngata.
Barack Obama referred to Poe while making a guest appearance on
The B.S. Report stating; "They just had the Combine and they were talking about some guy who's like 340 and runs a 4.8 and has a three-foot vertical," Obama said. "I don't know what you do if a guy like that hits you." Poe was originally perceived as "the ideal two-gap 3–4 nose tackle" due to his massive frame, but former NFL defensive lineman
John Thornton described Poe as "more of a move guy than a big space eater", able to play in a 4–3 defense, too. However, Thornton also uttered concerns over Poe's mediocre college career. According to Jonathan Bales of
The New York Times, Poe was "the ultimate boom-or-bust prospect—loaded with potential, but failing to capitalize on it in college." The
Sporting News compared Poe to
Ryan Sims and
Jimmy Kennedy, two highly selected lineman who "were immensely talented yet struggled because of inconsistent effort and competitiveness". In March 2012, Poe's draft stock peaked when he was listed at No. 9 by ESPN's
Mel Kiper, Jr., and No. 6 by
Sports Illustrateds Don Banks. "He'll be overdrafted," an unnamed NFL scout told the
Times of Trenton, while nevertheless acknowledging that "he's the most athletic over 300-pound man in this draft, or a lot of other drafts." After analysing game tape, Mike Mayock downgraded Poe from No. 1 to No. 4 among defensive tackles, describing him as "a freaky athlete with a good motor" who, however, "needs to get into a good locker room with a mentor in that defensive line group" to develop into a high-quality NFL player. While acknowledging his lack of production in college,
Bucky Brooks pointed out "Poe's blue-chip qualities (size, athleticism and strength) and the immense importance of the [nose tackle] position". According to
The Sporting Newss Russ Lande, Poe's draft stock plummeted in the weeks before the draft, amid concerns over his poor production at Memphis.
Sports Illustrated graded Poe as the No. 2 defensive tackle in the draft, behind only
Fletcher Cox. Eventually, he was the first defensive lineman off the board, selected eleventh overall by the
Kansas City Chiefs. Poe was the highest drafted player from Memphis since
Keith Simpson (No. 9 in
1978), and the highest drafted player from
Conference USA ever. He was also the third defensive lineman Kansas City selected in the first round within five years, following
Glenn Dorsey and
Tyson Jackson. Chiefs head coach,
Romeo Crennel, said he was not worried about Poe's mediocre college statistics, "because he played every down at 350 pounds and he played every position on the line in every game."
Kansas City Chiefs 2012 season Poe was expected to succeed veteran
Kelly Gregg at the defensive tackle position in Kansas City's 3–4 defense, although head coach Crennel acknowledged that "it's going to take a while for [Poe] to get adjusted." On the eve of training camp, July 26, 2012, Poe agreed to terms with the Chiefs, signing a four-year deal with a fifth-year team option. Per team policy, financial terms of the deal were not disclosed, but it was reported to be worth about $11 million. Competing with
Anthony Toribio and
Jerrell Powe for the starting nose tackle spot left void by Gregg, Poe disappointed in training camp. "He needs to work on technique, he needs to work on understanding the system, he needs to get the calls correct all the time. He's got a ways to go," said Crennel. After spending the first three preseason games on the bench, Poe was moved into the starting lineup after Toribio injured his
ankle. He established himself as a starter, and remained in the starting lineup for his entire rookie season, starting all 16 regular season games at nose tackle and being a three-down player for most of the season. He recorded 38 tackles, including 28 unassisted. Even though he did not record a
quarterback sack, he was credited for his contributions as an inside rusher in obvious passing situations. Particularly, his efforts against the
Pittsburgh Steelers in Week 10 and
Cincinnati Bengals in Week 11 were praised. In Week 15, he registered a season-best five tackles in a loss against
Oakland. According to
The Sporting News, Poe as a rookie appeared to be more advanced in grasping the Chiefs' two-gap system than either Dorsey or Jackson as a rookie.
2013 season After not recording a quarterback sack in his rookie season, Poe tallied 3.5 sacks over the first two games of the
2013 NFL season. Increasingly drawing double-teams afterwards, he only added one sack over the rest of the season. Twelve games into his sophomore season, Poe lined up on 804 defensive snaps, which was 85 more than any other defensive tackle in the NFL that season. After the 2013 season concluded, Poe was selected to participate in the annual
Pro Bowl.
2014 season During the 2014 season, Poe started all 16 games with six sacks and a pass defended on 46 tackles. He was selected to the Pro Bowl for a second year in a row.
2015 season During Week 11 against the
San Diego Chargers, Poe became the heaviest player in NFL history to rush for a touchdown. He was only the sixth defensive lineman to rush for a touchdown. In 15 games, Poe made 39 tackles, 1 sack, 1 forced fumble, and 1 fumble recovery.
2016 season Poe scored his second rushing touchdown in as many attempts—this time actually receiving a lateral pass—in an October game against the Oakland Raiders in a play called "Hungry Pig Right" where four players lined up in a diamond formation sending "over 1,100 pounds rushing toward the end zone." In a December 25 game against the
Denver Broncos in Week 16, Poe became the largest player in NFL history to throw a touchdown pass. After being put in on offense, he lined up in the
wildcat formation, took the direct snap, faked a run up the middle, then threw a touchdown pass to tight end
Demetrius Harris while jumping in the air. In the post game press conference, Chiefs head coach
Andy Reid called the play the "Bloated Tebow pass" referring to a play when
Tim Tebow was the quarterback at
Florida and he threw a touchdown pass while jumping after faking a quarterback sneak. In 16 games, Poe finished the year with 27 tackles, a forced fumble, 1.5 sacks, and three passes defended.
Atlanta Falcons On March 16, 2017, Poe signed a one-year, $8 million contract with the
Atlanta Falcons. Poe made a bonus of $125,000 after passing his July 26 weigh-in. He started all 16 games, making 39 tackles (4 for loss), 2.5 sacks, 10 quarterback pressures and 2 passes defensed.
Carolina Panthers in
2018. On March 15, 2018, Poe signed a three-year, $27 million contract with the
Carolina Panthers. In his first season in Carolina, Poe started all 16 games, recording 32 tackles, 6 quarterback pressures and one sack. In 2019, Poe played in 11 games with 8 starts, before suffering a torn quad in Week 12 against the
New Orleans Saints. He was placed on injured reserve on November 27, 2019. He finished the season with 19 tackles and four sacks. The Panthers declined the option on Poe's contract making him a free agent in 2020.
Dallas Cowboys On April 9, 2020, Poe signed a two-year contract with the
Dallas Cowboys. He was placed on the active/
physically unable to perform list at the start of training camp on July 28, 2020. He was moved back to the active roster on August 18, 2020. He was expected to start alongside
Gerald McCoy at
defensive tackle until he was lost for the season with a quadriceps tear injury. Poe started the first seven games mostly alongside
Trysten Hill, while registering 9 tackles and no sacks. He was part of a struggling defense, especially against the run. In the season opener against the
Los Angeles Rams, he became the first Cowboy to
kneel during the national anthem since the start of the movement in 2016. His defensive snaps began to decrease in Week 5, until being released on October 28, as part of a roster purge that included free agency acquisitions
Everson Griffen and
Daryl Worley. Team owner and general manager
Jerry Jones, attributed the move to Poe's lackluster performance and being overweight.
NFL statistics ==Personal life==