Gottlieb's first government position was at the
United States Department of Agriculture, where he researched the chemical structure of organic soils. He later transferred to the
Food and Drug Administration, where he developed tests to measure the presence of drugs in the human body. Gottlieb grew bored with this work and sought a more challenging position. In 1948, he found a job at the
National Research Council, where he described being "exposed to some interesting work concerning
ergot alkaloids as
vasoconstrictors and
hallucinogens." He soon relocated to the University of Maryland as a research associate dedicated to studying
metabolisms of
fungi. On July 13, 1951, Gottlieb reported for his first day of work for the CIA. Then-
Deputy Director for Operations Allen Dulles hired him on
Ira Baldwin's recommendation. Baldwin had founded and run the
biowarfare program at
Fort Detrick years earlier, and had kept Gottlieb in his orbit. Gottlieb had advanced knowledge about poisons. In the 1950s,
Communist infiltration concerned many Americans. These
Cold War-era fears also contributed to the CIA expanding its experimental methods over the next two decades, worrying that the
USSR and
The People's Republic of China had already mastered
brainwashing and were using it against their own citizens and prisoners.
Project BLUEBIRD was already underway when Gottlieb was brought on board; BLUEBIRD experimented with "Special Interrogation" techniques on captured prisoners at black sites like
Camp King and Villa Schuster, using drugs to attempt to break ego control and elicit information. BLUEBIRD lacked scientific knowledge and discipline; Dulles wanted Gottlieb to get it back on course. After proceeding through training, he was named chief of the newly formed Chemical Division of the
Technical Services Staff (TSS). On August 20, 1951, Dulles ordered BLUEBIRD to be expanded and centralized, and renamed the Project
Artichoke, which became a power base for Gottlieb. Dulles was promoted to
Deputy Director of Central Intelligence shortly after expanding Artichoke's scale. Dulles and Gottlieb both believed there was a way to influence and control the human mind that could lead to global mastery. They also wanted a "
truth serum", something that had been investigated during the days of the
OSS but never fully realized. Gottlieb conducted experiments using
THC, cocaine, heroin, and
mescaline before realizing
LSD had not been properly tested or investigated by the agency. After trying LSD for the first time himself, Gottlieb accelerated LSD experiments at the agency, testing it on agents who agreed to be dosed under controlled environments and some who agreed to be dosed by surprise. LSD had been synthesized only 13 years earlier. After months of experimenting on agents, Gottlieb sought help from the Special Operations Division at Detrick. Gottlieb's first 18 months at the agency led to some frustrating discoveries. The drugs he was experimenting with were not the "truth serums" he had hoped, and often hindered interrogations rather than aiding them. He knew Dulles, now the Director of Central Intelligence under
President Eisenhower, would approve his proposals. Gottlieb and
Richard Helms, then-Chief of Operations for Directorate of Plans, wrote a memorandum to send to Dulles. Dulles formally approved
Project MKUltra on April 13, 1953. His brother,
John Foster Dulles, was appointed
Secretary of State, giving further diplomatic cover to the project. On April 10, Dulles described the program and others like it in a speech to alumni of Princeton University, referencing the new battlefield of "brain warfare" as the battle for controlling the human mind. He described the program as something the Soviet Union was doing rather than something the CIA was pioneering. Gottlieb selected multiple researchers, scientists, and ex-OSS members to work for him under MK-ULTRA "subprojects." Those contracted conducted experiments on Gottlieb's behalf and reported their findings to him. He sponsored physicians such as
Donald Ewen Cameron and
Harris Isbell in controversial psychiatric research, including
non-consensual human experiments. Gottlieb administered
LSD and other
hallucinogenic drugs to unwitting subjects and financed psychiatric research and development of "techniques that would crush the human psyche to the point that it would admit anything". He was named as the person who gave Army bacteriologist
Frank Olson LSD at an MK-ULTRA retreat, leading to Olson's mental spiral and death a week later. s obscure much of the context.) Gottlieb was the liaison to the military subcontractor
Lockheed, then working for the CIA on
Project AQUATONE, later known as the
U-2 spy plane. In 1953, he arranged a
safe house for the Lockheed Aeronautics Services Division (LASD) with an easy and exclusive egress. By 1955 Project MK-ULTRA had outgrown its government funding. At this point Subproject 27 (basic research of LSD) was a funding subproject that combined previous subprojects, including payment to
Sandoz Pharmaceuticals for LSD,
John Mulholland's
The Official CIA Manual of Trickery and Deception (subproject 15 magic support, Mulholland Supplement), and further procurement of LSD (subproject 18), but it grew to almost 150 documented subprojects, including a microwave gun and the search for alternatives to LSD, which led to later programs like
Project MKCHICKWIT, most of which focused on South America. In addition to working with subcontractors, the CIA worked with the
Advanced Research Projects Agency (ARPA) of the
Department of Defense and the
Office of Naval Intelligence, though it is unclear what role Gottlieb played in these affairs other than authorization. In March 1960, under
The Cuban Project, a CIA plan approved by
President Eisenhower—and under the direction of CIA Directorate for Plans
Richard M. Bissell—Gottlieb proposed spraying
Fidel Castro's television studio with
LSD and saturating Castro's shoes with
thallium to make his beard fall out. Gottlieb also hatched schemes to assassinate Castro, including the use of a poisoned cigar, a poisoned wetsuit, an exploding
conch shell, and a poisonous
fountain pen. Gottlieb also played a role in the CIA's attempt to assassinate Prime Minister
Patrice Lumumba of the Congo. He took a vial of poison to the Congo with plans to place it on Lumumba's toothbrush in the summer of 1960. He provided these "toxic biological materials" to
Larry Devlin, the CIA station chief in the Congo, and although Devlin reportedly declined the assignment, a
military coup soon overthrew and killed Lumumba. ==Retirement and death==