Edmund took over the management of the Wood End factory in
Widnes, Lancashire, from his older brother
Frederic and also became involved in the management of his father's Liverpool factory. These factories manufactured
alkali by the
Leblanc process. During this time Edmund studied
metallurgy at
Owens College, Manchester and invented methods of separating nickel,
cobalt and copper from the waste by–products from his factories. He also operated a plant at Wood End to recover
sulphur by the process invented by
Ludwig Mond. In 1867 the Widnes Metal Company was formed with Muspratt as its chairman with the purpose of recovering metals, particularly copper and silver, from the burnt
pyrites used for alkali manufacture. In 1860 when the governments of Britain and France formed a treaty to raise
duties on materials made from salt, Muspratt was prominent in the establishment of an alkali manufacturers' association. Muspratt and
Holbrook Gaskell went together to Paris to negotiate terms for the manufacturers. The association was more formally established two years later to deal with problems arising from pollution. In 1876 Muspratt was a witness giving evidence to the
Royal Commission enquiring into the pollution caused by the Widnes factories. In 1890 many of the businesses using the Leblanc process combined to form the
United Alkali Company to resist competition from factories making alkali by the
ammonia–soda process. Muspratt became a director and later the president of this company. ==Politics and personal life==