George III had his first attack of madness, possibly attributable to
porphyria, which could have been triggered by an excess of rich wines, or more likely an over exposure to the
arsenic related to the elaborate hats commonly worn in the Georgian period (though this diagnosis has been challenged, with various other causes being put forward, such as bipolar disorder). The court physicians were baffled by the symptoms and failed to treat the King successfully. In 1788 Willis was recommended to the increasingly concerned
Queen Consort by an
equerry's wife, whose mother Willis had treated successfully. Willis's treatment of the King at The White House,
Kew, included many of the standard methods of the period, including coercion,
restraint in a strait jacket and
blistering of the skin, but there was also more kindness and consideration for the patient than was then the norm. When on 26 February 1789 Willis's bulletin described the "entire cessation of his Majesty's illness" he became a British celebrity and was soon recognised through five portraits by
John Russell, one of the most renowned portrait painters of the day. Willis commissioned a special medal to commemorate his own achievements. The Reverend Doctor Francis Willis was rewarded by the King with £1,500 a year for 21 years and assistant and son Dr John Willis with £650 a year for the rest of his life. The King's recovery made Willis's national reputation and he had to open a second establishment at nearby Shillingthorpe Hall (in the parish of
Braceborough) to accommodate the numbers of patients seeking his help. Shillingthorpe Hall was demolished in 1949. Twelve years later in 1801 King George suffered a relapse and his symptoms returned. On the second occasion he was treated by two of Francis's sons, also physicians, John Willis and his younger brother, Robert Darling Willis. The King had a final relapse in 1810 that proved incurable and he lapsed into an illness and madness that lasted until his death in 1820.
Treating Queen Maria I of Portugal Willis' fame would lead him to help Queen
Maria I of Portugal in 1792 who suffered from episodes of madness. His role was advisory and did not see success as in the case of King George III. His recommendations included psychotherapy and proper nutrition as opposed to medication. ==Legacy==