Early years Guilherme Smith is a product of the
Vasco da Gama,
Fluminense and
Botafogo academies, all from
Rio de Janeiro,
Brazil.
Zorya Luhansk In June 2021 he signed a 3-year contract with the
Ukrainian Premier League club
Zorya Luhansk. He made his debut on 28 October 2021 as a start-squad player in a winning away match against
Rukh Lviv in the Round of 16 of the
Ukrainian Cup.
Nõmme Kalju On 1 August 2024, Guilherme Smith joined Estonian side
Nõmme Kalju, on a contract until end of 2026, which also included an option to extend it for another year.
Union Saint-Gilloise On 12 August 2025, Smith signed for
Belgian Pro League club
Union Saint-Gilloise on a contract until 2029. ==Career statistics==