Main •
Melissa George as Dr. Alexandra Panttiere, the new Chief Innovation Officer (CIO) of St. Matthew's hospital, a cutting-edge
research hospital. She has a very idiosyncratic personality, and is constantly dealing with demons from her past history at the hospital. •
Dave Annable as Dr. Pierce Harrison, Alex's boyfriend and fellow surgeon. •
Don Hany as Dr. Jesse Shane, chief of surgery at St. Matthews, and Alex's former mentor from when she interned at the hospital. •
Shelley Conn as Dr. Millicent Silvano, hospital administrator. She is a stickler for procedure and the rules, much to Alex's chagrin. •
Joshua Leonard as Max Elliot, Alex's gay ex-husband •
Maya Erskine as Nurse Ji-Sung •
D. L. Hughley as Dr. Myron Hackett, hospital psychiatrist •
Jamie Kennedy as Dr. Casey Callahan, a surgeon in the hospital. •
JLouis Mills as Dr. Forester, the resident anesthesiologist who is blind in one eye.
Recurring • Caitlyn Larimore as Lynn • Greyson Foster as Gabrielle Elliot • Rudy Martinez as Marty • Adlu Fahrezy as Rudi ==Episodes==