Los Angeles Chargers Jackson was selected by the
Los Angeles Chargers in the seventh round (251st overall) of the
2018 NFL draft. He was waived on September 3, 2018, and was signed to the
practice squad the next day. He was promoted to the active roster on September 24, 2018. He made his professional debut in Week 4 against the
San Francisco 49ers. In a Week 6 game against the
Cleveland Browns, he recorded his first three professional carries, which went for four yards. In Week 13, against the
Pittsburgh Steelers on
NBC Sunday Night Football, he had eight carries for 63 yards and his first professional rushing touchdown. The following week against the
Kansas City Chiefs, Jackson made his first career start following injuries to
Melvin Gordon and
Austin Ekeler, rushing for 58 yards on 16 carries and scoring a touchdown. Overall, he finished the 2018 season with 206 rushing yards and two rushing touchdowns to go along with 15
receptions for 135 receiving yards. He made his postseason debut with two carries for five rushing yards in the 23–17 victory over the
Baltimore Ravens in the
Wild Card Round. He had three receptions for 22 yards in the 41–28 loss to the
New England Patriots in the
Divisional Round. In the 2019 season, Jackson finished with 29 carries for 200 rushing yards in seven games. Jackson entered the 2020 season as the No. 2 running back to Austin Ekeler. He suffered a knee injury in Week 9 and was placed on
injured reserve on November 14, 2020. He was activated on December 12, 2020. In Week 17 against the Chiefs, Jackson recorded 104 yards from scrimmage during the 38–21 win. Jackson finished the 2020 season with 59 carries for 270 rushing yards to go along with 19 receptions for 173 receiving yards. In Week 8 of the 2021 season, against the Patriots, Jackson had a career-long 75-yard run. In Week 15, against the Chiefs, Jackson led the Chargers in carries with 13 for 86 yards rushing and a 13-yard reception, totaling 99 yards from scrimmage. In Week 16, against the Texans, he recorded a career-high 162 scrimmage yards and 8 receptions to go along with his only two rushing touchdowns of the season in the 41-29 loss. In the 2021 season overall, Jackson finished with 68 carries for 364 rushing to go along with 22 receptions for 178 receiving yards in 14 games, all career-highs.
Detroit Lions On August 1, 2022, Jackson signed with the
Detroit Lions. He was released on August 30, 2022, and signed to the practice squad the next day. He was promoted to the active roster on September 14. He finished the 2022 season with 42 carries for 170 rushing yards and one rushing touchdown to go along with 12 receptions for 101 receiving yards and one receiving touchdown in 16 games. On July 22, 2023, Jackson re-signed with the
Detroit Lions. On August 10, 2023, he announced his retirement from professional football. ==Career statistics==