2000s In 2004, Palmer gained her first film role in
Barbershop 2: Back in Business. In 2005, she signed a record deal with
Atlantic Records. That same year, she was featured in the television film
Knights of the South Bronx, as well as starring in the television series
Second Time Around and
ER. That same year, producer
Ralph Farquhar helped Palmer book the starring role in a Disney Channel pilot titled
Keke and Jamal. The pilot was not picked up, and never aired. In 2006, Palmer had her acting breakthrough starring in the film
Akeelah and the Bee, playing the titular Akeelah, a bright 11-year-old who comes from a poor neighborhood and competes in the
Scripps National Spelling Bee. Moira Macdonald of
The Seattle Times wrote that Palmer "makes an appealing heroine". For the role, she won a
Black Reel Award and an
NAACP Image Award. She also had a supporting role in the 2006 film ''
Madea's Family Reunion. The following year, Palmer appeared in the thriller Cleaner. She portrayed a lead role in the television film Jump In!. Palmer also starred in two television programs Tyler Perry's House of Payne and Just Jordan. Palmer released her debut album So Uncool on September 18, 2007. The album charted at number 86 on the US Billboard''
Top R&B/Hip-Hop Albums chart. In 2008, Palmer began her starring role as the title character in
Nickelodeon sitcom
True Jackson, VP. Palmer also wrote and performed the
theme song for the series. Palmer earned $20,000 per episode of
True Jackson, VP, which made her the fourth-highest-paid child star on television. In July 2009, designer Jane Siskin created a
Walmart fashion line inspired by
True Jackson, VP, with all the designs being approved by Palmer. She also played the lead role in the 2008 film
The Longshots.
True Jackson, VP ended in 2011.
2010s Palmer debuted as the voice of Aisha in
Nickelodeon's revival of
Winx Club. She received an NAACP Image Award nomination for her voiceover work. In 2012, Palmer starred in the film
Joyful Noise, released in January 2012. She produced and starred in
Rags, a television musical film, as well as voiced
Peaches in
Ice Age: Continental Drift. In July 2012, Palmer released the single "You Got Me" featuring
Kevin McCall. The video for the single was released on July 11, 2012. She released a self-titled mixtape
Keke Palmer on October 1, 2012. In 2013, Palmer portrayed
Rozonda "Chilli" Thomas in the
TLC biopic,
CrazySexyCool: The TLC Story, which aired in October on
VH1. In 2014, she starred in the horror film
Animal, which was released on June 17. Palmer then recurred during the second season of
Showtime's drama series
Masters of Sex, portraying Coral, a nanny. That same year, Palmer hosted a daytime talk show on
BET titled
Just Keke. In doing so, she became one of the youngest talk show hosts in television history; the show itself has been regarded as "groundbreaking" and "refreshing". In September 2014, Palmer became the first African American to star as the title character in the musical
Cinderella on Broadway. She performed her final show during the closing night of the show's run on January 4, 2015. Later that year, Palmer announced that she had signed with
Island Records. Between September 2015 and December 2016, she starred as
Zayday Williams in the horror comedy series
Scream Queens, created by
Ryan Murphy. In January 2016, Palmer starred as Marty Maraschino in the television special
Grease: Live.
Rolling Stones Brittany Spanos regarded Palmer's performance "a standout" and highlighted her "assertiveness, confidence and biting sense of humor". In June, Palmer released
Waited to Exhale, an album she wrote during her time on
True Jackson, VP that went unreleased due to label issues and her "anxiety-driven hesitance". On November 4, Palmer released her second
extended play, titled
Lauren, with a 17-minute short film of the same name being released exclusively on
Billboards website. In 2017, Palmer released her memoir, ''I Don't Belong to You: Quiet the Noise and Find Your Voice
. That same year, she joined the drama series Berlin Station'' during its second season. In April 2019, Palmer began guest co-hosting
ABC's daytime talk show
Strahan and Sara, sporadically filling in for co-host
Michael Strahan and more regularly beginning in June during co-host
Sara Haines's
maternity leave. She joined the slasher television series
Scream as a series regular in its third season, portraying a character named Kym Johnson, which premiered on July 8, 2019. On August 26, Palmer became a third permanent co-host of
Strahan and Sara, which was then re-titled
Strahan, Sara and Keke. In September, Palmer starred as a "lovestruck stripper" in the crime drama film
Hustlers, directed by
Lorene Scafaria. She sang the song "Giants" as part of a virtual group named True Damage, in which she voices a character named Senna, in the video game
League of Legends for the
2019 World Championship. The song features singers
Becky G and
Soyeon as well as rappers
Duckwrth and
Thutmose as the other group members. In November, True Damage performed the song live during the opening ceremony of the finals.
2020s in 2024
Strahan, Sara and Keke ended unexpectedly in March 2020 when the
COVID-19 pandemic ended live studio programming through the industry, and ABC decided to shift the timeslot towards news. Palmer later received a
Daytime Emmy Award nomination for
Outstanding Entertainment Talk Show Host alongside Haines and Strahan. That same year, Palmer began starring in a web television comedy series titled
Turnt Up with the Taylors, in which she portrays all of the characters. She released an extended play titled
Virgo Tendencies, Pt. 1 on August 28. On August 30, Palmer hosted the
2020 MTV Video Music Awards, during which she also performed her song "
Snack". In December 2020, she released a follow-up EP
Virgo Tendencies, Pt. 2. The following year, Palmer won the
Primetime Emmy Award for Outstanding Actress in a Short Form Comedy or Drama Series for her performance in
Turnt Up with the Taylors. Later in the same year, Palmer briefly hosted a reboot of the classic 90's
MTV dating show
Singled Out with
Joel Kim Booster as her co-host for the short-lived online streaming service network
Quibi. In 2021, she hosted the reality competition series
Foodtastic for
Disney+. In 2022, Palmer starred in
Alice, directed by Krystin Ver Linden, which had its world premiere at the
2022 Sundance Film Festival. She served as narrator on
Not So Pretty, a documentary investigating the
beauty industry directed by
Kirby Dick and
Amy Ziering for
HBO Max. Palmer also voiced the character of Izzy Hawthorne in the
Pixar animated film
Lightyear, a spinoff of the
Toy Story film series. That same year, she starred as Emerald Haywood in the
Jordan Peele-directed science-fiction horror
Nope for which she received critical attention; her performance won the
New York Film Critics Circle Award for Best Supporting Actress. In August 2022, Palmer debuted as host of an
NBC reboot of the game show
Password, with
Jimmy Fallon as executive producer/permanent celebrity guest. For the last three episodes of ''
Karma's World'', in September 2022, Palmer voiced Cece Dupree, a conniving and ruthless rapper. On February 9, 2023, it was announced that Palmer was set to star alongside
Sacha Baron Cohen in the
David O. Russell film
Super Toys. The film is a period piece set in the 1970s. In June 2023, it was announced Palmer had been invited to join
The Academy as an actor. Palmer starred in
Usher's music video for his single "
Boyfriend", which was released on August 16, 2023. In June 2024, Palmer started a girl group called
DivaGurl; similar to
The Pussycat Dolls, where
Nicole Scherzinger is the lead singer, Palmer is the lead singer of DivaGurl. In 2025, Palmer co-headlined the film
One of Them Days with
SZA and received widespread critical acclaim. ==Other ventures==