St. Louis Cardinals Blasingame made his major league debut at age 23 on September 20, 1955, in a 2–0 Cardinals win over the
Chicago Cubs. Starting at second base and batting leadoff, his first career at bat resulted in his first hit, a single off
Sam Jones, and he scored on a
Solly Hemus home run. He appeared in five games that fall for the Cardinals, reaching base 12 times in 23 opportunities. He batted .263 in his first 50 games, through June 12. Two days later, the Cardinals traded Schoendienst to the
New York Giants, opening the door for Blasingame to take over at that position. He spent the rest of the year at second base and finished the season batting .261 with 153 hits, 94
runs, and 27 RBI in 150 games (587 at bats). He stole eight bases but was caught an equal number of times. September 4, he had an even better game against the Braves. With the game tied 4–4 in the 12th inning, Blasingame hit a
double against
Don McMahon with one out. He then stole third base, forcing McMahon to
intentionally walk the next two hitters to set up a
force play. An error by
Bob Hazle allowed Blasingame to score, giving the Cardinals a 5–4 win. Another highlight came on June 12 that year, when he had four RBIs, including a two-RBI single in the 10th inning, helping the Cardinals beat the
Pittsburgh Pirates 10–3 in the first game of a
doubleheader. Used as a leadoff man, Blasingame led the
National League (NL) with 650 at bats. Defensively in 1957, Blasingame led NL second basemen in
assists and
double plays. In 1958, Blasingame batted .276 in the first half of the season, getting named to the
National League All-Star team for the only time in his career.
Bill Mazeroski played the whole game for the NL at second, but Blasingame did make an appearance, flying out when he
pinch-hit for
Warren Spahn in the fourth inning.
Sports Illustrated reported he was "hurt a lot" that year, but he still appeared in 143 of 154 games. He batted .274 with 71 runs scored, 19 doubles, 10
triples (a career high), two home runs, and 20 steals. He had three hits, scored three times, and drove in two runs during a June 9, 12–3 victory over Milwaukee. On July 19, he had four hits and scored twice in a 9–5 victory, also over Milwaukee. He finished the season with a .289 batting average and 26
doubles, both career highs. While he only had 24 RBI, he scored 90 runs. He stole 15 bases but was caught a league-leading 15 times as well. He served as the team's leadoff man, just as he had in St. Louis. However, Blasingame failed to live up to expectations with the Giants. His batting average dropped to .235, the lowest of his major league career. In 136 games (523 at bats), Blasingame had 123 hits, two home runs, and 31 RBI. He did see improvement as a base stealer, as he was only caught stealing twice in 16 attempts. He was only used three times in the first two weeks, all as a pinch-hitter, before getting traded with
Bob Schmidt to the
Cincinnati Reds for
Ed Bailey and a
player to be named later (
Sherman Jones). "We needed some one to pull the infield together...Blasingame fit the bill," said Reds' manager
Fred Hutchinson. In 123 games (450 at bats), Blasingame had 100 hits, one home run, and 21 RBI, only stealing four bases on the season. On April 18, he had three hits, four runs, and two RBI in a 14–0 victory over the Dodgers. On May 24, he had four hits, including a double and a triple, in a 5–0 victory over the
Houston Colt .45's. He had five hits against the Cubs in a 7–5 victory over them in Game 1 of a doubleheader held on September 5. In 141 games (494 at bats), Blasingame had 139 hits, scored 77 runs, had two home runs, and drove in 35. Once again, he stole four bases. His extra-base hit totals were down, as he had nine doubles and seven triples. The Reds had a new second base prospect in spring training that year named
Pete Rose; Blasingame was the only member of the team who thought he would make the roster. Rose went on to win
Rookie of the Year honors that year. Though Rose won the second base job, he lost it temporarily to Blasingame after batting .130 in the first six games of the year. Blasingame played the next eight games there but batted .160 and lost the job to Rose again. Blasingame finished the 1963 season strong, batting .316 in his final 32 games beginning August 24. In 69 games (254 at bats) with the Senators, he batted .256 with 29 runs scored, 65 hits, two home runs, 12 RBI, and three stolen bases. In 87 games (285 at bats) between Cincinnati and Washington, he batted .246 with 33 runs scored and 70 hits (he had no home runs, RBI, or stolen bases with the Reds). On May 29, he pinch-hit in the sixth inning, drew a walk, scored the tying run, then had a two-RBI single against
Ted Abernathy in the next inning to help the Senators beat the
Cleveland Indians 8–4. August 4, he hit a bases-loaded two-RBI single against
Sonny Siebert, putting the Senators ahead to stay in a 4–2 victory over Cleveland. He played 143 games (506 at bats) for the Senators, batting .267 with 56 runs scored, 135 hits, 17 doubles, one home run, and 34 RBI. Three days later, he had three hits and drove in the Senators' only run in a 2–1 loss to the
Chicago White Sox. His two-run single against
Pete Mikkelsen on July 18 helped the Senators win a 3–0 victory over the Yankees. From August 22 through September 3, the Senators opted to play
Ken Hamlin at second base instead of Blasingame. Blasingame only played 129 games (403 at bats) for the Senators in 1965, batting .223 with 90 hits, 47 runs scored, eight doubles, eight triples, one home run, and 18 RBI, stealing five bases. Blasingame's only home run of the year came against
Dave Wickersham, a solo shot in a 4–3 loss to the
Detroit Tigers on June 13. In the first game of a doubleheader against Boston on July 4, he struck out a season-high three times but had two RBI in Washington's 6–4 win over the Red Sox. He batted .218 with 43 hits, 18 runs scored, 11 RBI, and nine doubles in 68 games (200 at bats) through the end of July. On August 2, the
Kansas City Athletics purchased his contract. Blasingame was mainly used as a pinch-hitter with Kansas City, only starting three games. He played 12 games for the Athletics, getting three hits in 19 at bats. Following the
September call-ups, the Athletics released him on September 7. In 68 games his final year, Blasingame batted .210. He finished his time in the major leagues as a .258 career hitter with 1,366 hits, 178 doubles, 62 triples, 21 home runs, and 308 RBI in 1,444 games (219 at bats), stealing 105 bases. ==The only hit==