Early career Omeruo had spells at
Sunshine Stars and
Anderlecht as a trialist before he was signed from the Anderlecht academy by
Standard Liège.
Chelsea In January 2012, Chelsea signed Omeruo from Liège and immediately loaned him out to
Eredivisie club
ADO Den Haag. In May 2014 Nigeria World Cup-bound Omeruo agreed a new three-year contract with
Chelsea.
Loan to ADO Den Haag Omeruo joined
ADO Den Haag on an 18-month loan deal which kept him at the club until the end of the 2012–13 season. On 3 March 2012, Omeruo made his debut for ADO Den Haag against
Heerenveen, which ended in a 0–0 draw. On 19 April 2012, in a game against
Groningen, Omeruo scored his first goal for ADO Den Haag. On 28 April 2012, Omeruo scored against
VVV in the 19th minute. He is the only player in the Dutch league ever to score a goal, an own goal and receive a red card in one match.
Loan to Middlesbrough On 7 January 2014, Omeruo joined
Middlesbrough on loan until the end of the
2013–14 season. On 1 February 2014, Omeruo made his debut for Middlesbrough in a 0–0 draw against
Doncaster Rovers. On 8 April 2014, Omeruo was sent off in the 82nd minute after picking up a second yellow. Although Boro had to finish the game with nine men (
Ben Gibson was also sent off late in the game), they still managed to earn a 3–1 win victory against
Birmingham City. He rejoined Middlesbrough for the
2014–15 season, making his first appearance against
Birmingham in a 2-0 win.
Loan to Kasımpaşa On 21 July 2015, Omeruo joined
Kasımpaşa on a season-long loan with an option to purchase the player at the end of the spell. On 16 August 2015, Omeruo made his debut for Kasımpaşa in a match against
Gaziantepspor, the match ended in a 3–0 victory for Kasımpaşa. Five days later, Omeruo made his home debut against
İstanbul Başakşehir, which ended in a 1–0 victory for Kasımpaşa. Omeruo had an up and down season, suffering from a couple injuries, however started whenever he was fit. Although the loan deal had an option to buy, Kasımpaşa decided to pass on the option due to a lack of funds, which led to Omeruo returning to Chelsea for pre-season.
Loan to Alanyaspor On 31 August 2016, Omeruo signed a one-year contract extension until 2019, before leaving on loan again. He joined
Alanyaspor on a season-long loan. On 25 February 2017, Omeruo scored his first goal for Alanyaspor in their 4–1 home victory over
Adanaspor, netting in the hosts' second in the 37th minute. In May 2017, Omeruo said he might have to leave Chelsea in order to play regular first-team football.
Return to Kasımpaşa On 25 August 2017, after signing a new three-year deal at Chelsea, Omeruo returned to
Kasımpaşa on a season-long loan.
Leganés On 15 August 2018, Omeruo joined
Leganés on a season-long loan. In October 2018, he stated that he was enjoying playing in Spain, and in March 2019, he said he wanted to sign for Leganés permanently. On 13 August 2019, Omeruo returned to Leganés, this time on a permanent deal, ending his seven year spell at Chelsea.
Third spell at Kasımpaşa On 27 July 2023, Leganés announced the transfer of Omeruo to Kasımpaşa. ==International career==