Films '' at the 34th
Toronto International Film Festival in September 2009 Cole made her acting debut as Polly in the 2007 comedy ''
St Trinian's'', a rework of the black and white
films of the 1950s and '60s, alongside
Rupert Everett,
Colin Firth,
Russell Brand,
Jodie Whittaker and
Stephen Fry. Her first leading role came in
Terry Gilliam's 2009 fantasy film,
The Imaginarium of Doctor Parnassus, playing Valentina, the teenage daughter of
Christopher Plummer's title character, Dr Parnassus, whom Parnassus has promised to the Devil (
Tom Waits) upon her 16th birthday. Acting alongside
Heath Ledger (who died before filming had finished), Cole, in an interview for the
Daily Telegraph admitted that, at times, she felt out of her depth in the role—saying "I'd only done a couple of films and here I was surrounded by amazing actors like Christopher Plummer and Heath Ledger, and it was intimidating at times", also describing the role as "the biggest role I've ever done". while Ryan Michael Painter wrote of the film on 'inthisweek.com' that "all of the performances are delightful, particularly Cole's as Valentina, proving that the haute couture model has more to offer this world than a pretty face". Cole appeared at the 34th
Toronto International Film Festival in December 2009 to promote
Parnassus. She was featured as herself in one episode of the online series
T Takes, a series of short, improvised films published by
The New York Times. Cole appeared as "Lettuce Leaf", a celebrity supermodel in the 2009 film,
Rage, directed by
Sally Potter. Cole also played "Aline" in the 2011 film
There Be Dragons. Cole had another minor role in
Primal Scream's 2008 video "Can't Go Back", in which she and other models featured in a horror-style video based on the films of
Dario Argento. The models, including Cole, are graphically "murdered" and "meet their ends in rather striking ways" with the aim of looking "hot even when dead". Cole again starred in a music video for Paul McCartney's song "Queenie Eye" featuring a number of actors and musicians including Gary Barlow, James Corden, Jude Law and Johnny Depp. It was reported in October 2009 that Cole would make her stage debut at the
Old Vic Theatre in London's
West End at the theatre's annual "24 Hour Plays" held in November, but "scheduling commitments" forced her to pull out. Cole ultimately made her stage début at the ADC Theatre in
Cambridge, as Nina in a student production of
The Seagull. She appeared in "
The Curse of the Black Spot", the third episode of the
sixth series of science fiction series
Doctor Who, in May 2011. She played a Sea
Siren. Cole stars in the music video for
Yeah Yeah Yeahs' 2013 single "
Sacrilege" as a woman burned alive by the many men and women with whom she has had affairs. In 2017, Cole starred in the
title role in the three-part
docu-drama miniseries
Elizabeth I, which aired on
Channel 5 from 9 to 23 May. ==Charity work==