USFL Dupree was signed by the
New Orleans Breakers of the
United States Football League in 1984. The upstart league had initially sworn off underclassmen in hopes of appeasing college coaches and officials angered by the blockbuster signing of
Herschel Walker after his junior year. However, after a federal judge ruled that the eligibility rule violated antitrust law, the Breakers–who had just moved from
Boston–quickly persuaded the
New Jersey Generals to give up their territorial rights to Dupree (OU was among the Generals' territorial schools) in return for their first-round pick in the
1985 USFL draft. after a five-and-a-half-year absence from the football field. In April that year, he asked his former USFL coach,
Dick Coury, then the quarterbacks coach for the Rams, if he could work out for the team if he got into shape, and impressed Coury and head coach
John Robinson enough to earn a contract. Dupree was placed on injured reserve, meaning he would have to sit out for four weeks before he could play for the Rams. During week nine of the
1990 season, Dupree made his first appearance and rushed for 22 yards on four carries, wearing number 34 in honor of Payton instead of his usual 22. He started his first game in week 16 and rushed for 42 yards on 13 carries. He finished his first NFL season with 72 yards on 19 carries, in three games played. In
1991, Dupree missed the first seven games due to a toe injury suffered in practice. Returning in week 8, he played more often and scored his only NFL touchdown that year. He finished the season with 179 yards on 49 carries with one touchdown, in eight games played. The
San Francisco 49ers brought Dupree into training camp in 1992 to play
fullback, a position he had never played. Before the
1992 season, Dupree led the Rams in rushing in the preseason, which included a 100-yard game in the final preseason game against the
Los Angeles Raiders, but was one of the 14 players cut by coach
Chuck Knox to trim the team down to the 47-player regular-season roster, and he retired shortly afterward. Knox, who had replaced John Robinson earlier that year, had told Dupree and the press that Dupree was not versatile enough for his one-back offense. He said he preferred running backs who "were a little more well-rounded, could catch the ball coming out of the backfield and could do some of the other things besides run with the football." He finished his career with 251 yards on 68 carries during regular season play, for a 3.7 yards-per-carry average, rushing for one touchdown. ==Career statistics==