The
Guardians of the Galaxy help defend
Xandar from an attack by
Kang the Conqueror, who uses his time crystal to summon
Eson the Searcher. After the Guardians defeat Eson, Kang's ship, the
Damocles, launches devices which cause a section of Xandar to disappear. Meanwhile, at
Avengers Mansion,
Nick Fury presents the
Avengers with several missions:
Captain America,
She-Hulk, and
Thor fight the
Presence in
Siberia;
Iron Man and
Captain Marvel defeat
Attuma at his underwater base; and
Spider-Man,
Ms. Marvel, and
White Tiger battle escaped
Raft prisoners on the
Brooklyn Bridge, including most of the
Sinister Six. The Guardians of the Galaxy arrive just before Kang uses his devices to steal
Manhattan with the heroes inside it and make it part of his battle arena called
Chronopolis, consisting of various locales that he has stolen from across time and space with his citadel at the center. Captain America leads a team through a portal to medieval England, where they help
Sir Percy reclaim his castle from
Enchantress and the
Black Knight. Another team led by She-Hulk follows
Klaw and the Hydra Four through a portal to
Wakanda, where
Black Panther joins them to fight
Man-Ape in the
vibranium mines. The heroes converge in a version of Manhattan ruled by
Hydra, where they battle Klaw and vibranium robot soldiers created by
Arnim Zola, and defeat
Baron Zemo in a
dogfight. Thor, Captain Marvel, and She-Hulk then travel to a swamp where they defeat
Man-Thing. Kang reveals that Man-Thing was guarding the
Nexus of All Realities, which separated the realms of Chronopolis. Kang destroys the Nexus, which drops the barriers between the locations, and challenges the heroes to rise up and face him. Regrouping at Avengers Mansion, the heroes detect a faint signal from outside Chronopolis. Searching for a device to boost its strength, the Guardians travel to the
Old West where they battle
MODOK and the
Circus of Crime. Retrieving the device, they learn that the signal is being sent from
Knowhere by
Cosmo the Spacedog. The heroes plan to retrieve the fragments of the Nexus to bring Knowhere into Chronopolis and use its energies to bring down the barrier surrounding Kang's citadel. In preparation,
Doctor Strange leads a team to the
Sanctum Sanctorum where they fight
Baron Mordo and retrieve the Book of the Vishanti, while Thor leads a party to an apocalyptic version of
Asgard to enlist the aid of
Heimdall, facing
Loki and
Surtur in the process. The search for the five Nexus fragments again splits the heroes into teams Spider-Man's group visits the
Marvel Noir version of Manhattan, where they help
Iron Fist,
Daredevil,
Luke Cage, and
Spider-Man Noir defeat the
Kingpin. Iron Fist accompanies them to
K'un-L'un, where they fight
Steel Serpent to free
Shou-Lao and retrieve a Nexus fragment. Proceeding to the
Alchemax building in
Marvel 2099's Nueva York,
Spider-Gwen and
Spider-Man 2099 help the group defeat the
Green Goblin 2099 and "Carnom" (a fusion of
Venom and
Carnage) to obtain another fragment. Meanwhile, the Guardians defeat
Ronan the Accuser, who has a Nexus fragment, in the
Kree home world of Hala, but are brainwashed by the
Supreme Intelligence. After stopping a
coup by
Maximus in
Attilan, the
Inhuman royal family rescue the Guardians, defeat the Supreme Intelligence and agree to join them in defeating Kang. At the same time, Captain America's group travels to the underwater city of Lemuria, but falls into a trap set by Attuma and are forced into Sakaar where Red King pits them against the "World Breakers" (consisting of
Hulk,
Red Hulk,
Maestro, and Greenskyn Smashtroll). Joined by the Hulk and
Stingray, they return to Lemuria, defeat Attuma and
Torg, and retrieve a Nexus fragment. Moving on to
Ancient Egypt, they enter a
Sphinx and join Horus of the
Heliopolitans in facing Loki and
N'Kantu, the Living Mummy to obtain another fragment. As Kang observes the heroes' exploits and plots to destroy them, his wife
Ravonna becomes increasingly disturbed by his actions. With the fragments gathered, the heroes assemble a device to bring Knowhere through a portal opened by Doctor Strange. Their first attempt nearly brings
Ego the Living Planet instead because of Kang's interference. Once Knowhere is in Chronopolis, they use an
electromagnetic pulse to knock out the energy shield protecting Kang's citadel. As the heroes begin their assault, Kang summons the
Damocles. Iron Man, Spider-Man, and
Star-Lord disable the ship, battling
Korvac and escaping before it crashes. Captain America, Captain Marvel, Doctor Strange, and Star-Lord enter the citadel and face Kang, who grows to gigantic size, uses the time crystal to reverse the
Damocles' destruction, and wields it as a sword. Captain America creates a giant solid hologram of himself and uses it to defeat Kang. Ravonna betrays Kang and uses the time crystal to turn him into a baby. The heroes celebrate their victory, and Ravonna promises to return the components of Chronopolis to their original places in time and space once the remaining villains are dealt with. In a
post-credits scene, everything is restored to normal. While visiting the
Statue of Liberty, Iron Man, Captain America, and Captain Marvel are visited by Ravonna (now known as "Terminatrix"), an elderly Kang, the Supreme Intelligence, Cosmo, and Man-Thing, who ask for their help in fixing a "chronal fracture". ==Audio==