2000s: Early roles and breakthrough screening of ''
Jennifer's Body on September 10, 2009In 2001, Fox made her acting debut in the romantic comedy Holiday in the Sun, as spoiled heiress Brianna Wallace and rival of Alex Stewart (Ashley Olsen), which was released direct-to-DVD on November 20, 2001. In the next several years, she guest-starred on the sitcoms What I Like About You and Two and a Half Men. Fox also appeared as an uncredited extra in the action film Bad Boys II'' (2003). In 2004, Fox made her feature film debut opposite
Lindsay Lohan in the musical comedy
Confessions of a Teenage Drama Queen, playing the supporting role of Carla Santini, a rival of Lola (Lohan). She was also cast in a regular role on the
ABC sitcom
Hope & Faith, in which she portrayed Sydney Shanowski, replacing
Nicole Paggi. Fox appeared in the second and third seasons, until the series was canceled by ABC in May 2006. In 2007, Fox won the lead female role of
Mikaela Banes in the 2007 live-action film
Transformers, based on the toy and cartoon saga of the same name. Fox played the love interest of
Shia LaBeouf's character Sam Witwicky. Fox was nominated for an
MTV Movie Award in the category of "Breakthrough Performance", and was also nominated for three
Teen Choice Awards. reprising her role as Mikaela in
Transformers: Revenge of the Fallen. There was controversy surrounding Fox's appearance while filming the sequel when
Michael Bay, the film's director, ordered the actress to gain ten pounds. The film was released worldwide on June 24, 2009, to box office success. Fox was to star in the third installment,
Transformers: Dark of the Moon, but was not included because of
her statements comparing working under director Bay to working for
Hitler. She confessed on GQ Magazine that she had lost approximately 30 pounds during filming due to consuming a primary diet of water and vinegar, and reportedly had a dispute over her visible loss of weight with the director on set. Bay stated in June 2009 that Fox was fired on orders of executive producer
Steven Spielberg, a claim Spielberg denied. In 2009, Fox had her first lead role since the
Transformers series; she portrayed the title character in ''
Jennifer's Body'', written by
Academy Award–winning screenwriter
Diablo Cody. The film initially earned mixed to average reviews upon its release, with Fox's performance earning praise. However, the film grew a cult following over time and was critically reassessed as a "forgotten feminist classic". According to Cody, the film was marketed incorrectly by executives who focused their efforts on the young male audience. In April 2009, she began filming the western superhero film
Jonah Hex, in which she portrayed
Tallulah Black / Leila, a gun-wielding beauty and Jonah Hex's (
Josh Brolin) love interest. The film was released on June 18, 2010. Despite receiving top billing, Fox described her role in the film as being a
cameo.
Jonah Hex was a critical and commercial failure in the US, with its international distribution canceled after its poor performance. The film was named the "worst picture of the year" by the
Houston Film Critics Society.
2010s: Rise to prominence '' screening in Sydney on September 7, 2014 Fox starred alongside
Mickey Rourke in the drama
Passion Play. After premiering at the Toronto International Film Festival, its conventional theatrical distribution was bypassed for a direct-to-video release, with only two screens briefly showing the film to fulfill contractual obligations. Rourke remarked that the film was "terrible. Another terrible movie." Fox appeared with
Dominic Monaghan in the music video for
Eminem and
Rihanna's single "
Love the Way You Lie". In 2012, Fox appeared briefly in
Sacha Baron Cohen's comedy film
The Dictator and had a featured role in
Judd Apatow's comedy film
This Is 40. She voiced the role of
Lois Lane in the animated comedy film
Robot Chicken DC Comics Special, an episode of the television comedy series
Robot Chicken that aired as a one-off special during
Cartoon Network's
Adult Swim programming block on September 9, 2012. In January 2013, Fox was featured in a Brazilian television commercial for
Brahma beer. In February 2013, Fox set aside her differences with her former director Michael Bay and worked again with him on his reboot of
Teenage Mutant Ninja Turtles (2014), starring as the lead human character of
April O'Neil. In 2015, Fox was cast in the role of Amelia Delthanis in the
Plarium video game,
Stormfall: Rise of Balur. In October 2015, it was confirmed that Fox would be temporarily replacing
Zooey Deschanel in the television sitcom
New Girl, following Deschanel's maternity leave. She starred as Reagan Lucas, appearing in the
fifth and
sixth seasons of the series. Her performance earned positive reviews from critics. In 2016, Fox reprised her role as April O'Neil in the sequel
Teenage Mutant Ninja Turtles: Out of the Shadows. On September 12, 2018, it was confirmed that Fox would star in the
Korean War film
The Battle of Jangsari, beside Korean actor
Kim Myung-min. She played a lead role as
Marguerite Higgins, an American news reporter. In 2019, Fox starred in the mystery-fantasy film
Above the Shadows opposite
Olivia Thirlby and
Alan Ritchson, directed by
Claudia Myers. It was released on July 19, 2019, by
Gravitas Ventures. That same year, Fox appeared in
Zeroville directed by
James Franco, which had been shot in 2014. The film was panned by critics and performed poorly at the box office.
2020s work In 2020, Fox starred opposite
Josh Duhamel in the family comedy film
Think Like a Dog, which was released on
video on demand on June 9, 2020. Also that year, she starred in the lead role of the action film
Rogue, which was released on August 28, 2020. In 2021 she starred in two thrillers:
Midnight in the Switchgrass opposite
Emile Hirsch and
Bruce Willis, directed by
Randall Emmett; and
Till Death, directed by S.K. Dale. In 2022 Fox starred in the drama comedy
Big Gold Brick, alongside
Oscar Isaac,
Andy García,
Lucy Hale, and
Emory Cohen, directed by Brian Petsos. Fox also played a role in the film
Taurus, a musical drama, alongside
Machine Gun Kelly,
Naomi Wild, and
Lil Tjay. In 2023, Fox was featured on the cover of the
Sports Illustrated Swimsuit Issue. Fox played crime boss Alana in the 2023 thriller film
Johnny & Clyde with Tyson Ritter. Fox played Gina in the fourth Expendables film,
Expend4bles, and voiced Nitara in the video game
Mortal Kombat 1, both released in September of the same year. In November 2023, Fox released her first book, titled
Pretty Boys Are Poisonous, a collection of her own poetry. Fox starred as Alice, a lifelike artificially intelligent android, in
Subservience, which was released in September 2024. In December 2025, Fox voiced Toy Chica in the film ''
Five Nights at Freddy's 2''. ==Public image==