Tampa Bay Buccaneers Clayton was selected by the
Tampa Bay Buccaneers with the 15th selection of the first round of the
2004 NFL draft. After a promising
2004 rookie campaign with Tampa Bay, where he led all NFL rookies and the Buccaneers with 80 receptions for 1193 yards, and his team with 7
touchdowns, Clayton had a relatively disappointing season in
2005. With knee surgery in the offseason that saw him having to play into shape in training camp, he finished with 32 receptions for a total of 372 yards and no touchdowns. He was forced to sit out the final game of the regular season against the
New Orleans Saints with a
turf toe injury and also sat out the Buccaneers playoff match-up against the
Washington Redskins. The start to the
2006 season showed that Clayton had returned to his healthy past of 2004. Clayton had 3 receptions and 34 yards despite the Buccaneers offensive struggles on September 10 in a 27–0 loss to the
Baltimore Ravens. Continuing his return to his 2004 form, he caught 6 passes for 55 yards and a touchdown against the
Cincinnati Bengals on October 15, 2006. His touchdown, thrown by
Bruce Gradkowski, came with seconds left and gave the Tampa Bay Buccaneers the go ahead lead for their first win of the 2006 season. However, the Buccaneers placed him on
injured reserve in December with a sprain he believed was occurring in his MCL of his left knee, ending his season with four games remaining. He followed that overall performance with a
2007 season that was thought to be a possible make or break season. He caught 22 passes during his 14-game season, 16 of those came in the last four contests and 10 coming in the last two. He also amassed 192 of his 301 yards in those four games. Clayton got to play in his first post-season contest on January 6, 2008, against the eventual Super Bowl-champion
New York Giants. He caught 3 passes for 39 yards. After the 2008 season, Clayton became a
free agent but re-signed with the Buccaneers to a new five-year deal. After signing the deal, he made the famous "check is in the bank" quote. The Bucs released Clayton on September 4, 2010.
United Football League Clayton joined the
Omaha Nighthawks of the
United Football League on October 25, 2010.
New York Giants On November 23, 2010, Clayton signed a one-year contract with the
New York Giants following injuries to Giants receivers
Steve Smith,
Hakeem Nicks and
Ramses Barden. The move also reunited Clayton with Giants quarterback
Eli Manning with whom he shared a
dorm during the NFL combine in 2004. On September 3, 2011, Clayton was cut by the Giants. On September 23, 2011, the Giants re-signed Clayton after placing
Domenik Hixon on
injured reserve. In the 2011–2012 season, Clayton and the Giants beat the Patriots in the Super Bowl 21–17, earning Clayton his first Super Bowl ring. He became a free agent after the season. ==NFL career statistics==