Early career / Paris Saint-Germain In 1997, Cana joined the local club
Dardania Lausanne, an amateur side founded by the
Albanian community in
Lausanne and coached by his father, Agim. He played at Dardania until 2000, when he was spotted and signed by French club
Paris Saint-Germain. While still at Dardania, Cana was invited for a trial with
Arsenal in 2000 at the age of 16 but was unable to attend because he was denied a British visa. He spent three seasons developing through the PSG ranks. During the
2000–01 season, while still involved with the youth sides, Cana made only four appearances with the reserves. The following season (
2001–02), he suffered a knee injury but managed 12 appearances and scored his first goal. The following season (
2002–03), he became a regular, making 21 appearances and scoring once, as the team won Group A of the league and earned promotion to
Championnat National 1. He went on to make two further appearances that season. During the
2003–04 season, Cana established himself as a starter under coach
Vahid Halilhodžić and was paired in midfield with another young defensive player,
Modeste M'bami. Cana remained a regular fixture for PSG throughout the following season (
2004–05). He made his European debut in the
UEFA Champions League group stage on 14 September 2004, playing the full 90 minutes in a 0–3 home loss against
Chelsea. A week later, he scored his first goal of the season, opening the scoring in the 45th minute of a 2–2 draw against
RC Lens. Throughout the Champions League group stage, Cana was ever-present, starting in all six matches and helping PSG to notable results, including a home win and an away draw against reigning champions
Porto and a draw against Chelsea. However, two defeats to
CSKA Moscow left the team bottom of Group H. Cana also made one appearance each in the
Coupe de France—where PSG reached the Round of 16—and the
Coupe de la Ligue, exiting in the third round. In total, he recorded 40 appearances across all competitions for the season, receiving 11 yellow cards. He finished his first season at the club with 43 appearances in all competitions — 28 in Ligue 1, six in the Coupe de France, one in the Coupe de la Ligue and eight in the
UEFA Cup 2005–06. Marseille recorded 60 league points, improving on the previous campaign to finish fifth in the table and qualify for the
2006 UEFA Intertoto Cup. The club also reached the
2006 Coupe de France Final, losing 1–2 against Cana's former side PSG. He retained his starting place during the
2006–07 season under coach
Albert Emon. Cana featured in 33 full league matches as Marseille finished runners-up with 64 points, behind
Lyon. He captained the team throughout the
2006–07 Coupe de France, leading them to another final, which Marseille lost 4–5 on
penalties to
Sochaux-Montbéliard after a 2–2 draw, with Cana successfully converting his spot-kick.
2007–08 season in 2008 Cana was named the club's
captain following the departure of
Habib Beye to
Newcastle United in the summer of 2007. In his first season as captain, he led the team in 34 out of 38 Ligue 1 matches, helping Marseille finish third and qualify for the following season’s
UEFA Champions League. Cana also appeared in all six
Champions League group stage fixtures. Marseille became the first
French club to win at
Anfield, defeating
2007 runners-up Liverpool 1–0, and collected six points from their opening two matches. Despite a strong start, they eventually finished third in their group, qualifying for the
2007–08 UEFA Cup final phase, where Marseille eliminated
Spartak Moscow before being knocked out by eventual winners
Zenit Saint Petersburg. Cana missed the first leg of the round of 16 through suspension but returned for the second leg, playing the full 90 minutes. He was soon handed the captaincy by manager
Steve Bruce, although Bruce initially stated that the team's permanent captain had yet to be decided. Cana made his Premier League debut on 15 August 2009, delivering an impressive performance in a 1–0 away victory over
Bolton Wanderers, becoming the first Albanian footballer to appear in the Premier League. On 3 September 2009, he was officially appointed as Sunderland’s club captain for the
2009–10 season. He made 35 appearances in all competitions, leading the team to a 13th-place finish in the league, the
FA Cup fourth round, and the
EFL Cup round of 16.
Galatasaray Cana joined
Galatasaray on 8 July 2010 for a €4.5 million transfer fee. He signed a four-year contract worth €2 million per season, plus bonuses based on appearances. During November 2010, Cana suffered an ankle injury which briefly sidelined him from the squad. He was soon reinstated as a key starter under new coach
Gheorghe Hagi, who was appointed shortly afterwards. Under Hagi, Cana became an undisputed starter, playing nearly all matches for 90 minutes and regaining his form and confidence. On 23 March 2011, following continued poor results that left the team outside the top 10, Hagi was dismissed from his position as head coach.
Bülent Ünder was appointed as interim manager for the remaining eight league matches of the season. Cana featured only briefly during this period due to a muscle tear injury that sidelined him for several weeks.
Lazio On 3 July 2011, Cana completed a transfer to Italian
Serie A club
Lazio as part of
Fernando Muslera's transfer to Galatasaray. The transfer was completed for €800,000 with the player signing until June 2016 with a wage of €1.7 million per season. His first score-sheet contributions came on his 7th Lazio appearance later on 10 December versus
Lecce, netting the second of the match only one minute after coming on in an eventual 2–3 away win. Cana's first months at capital club were marred by constant niggling injuries and on 31 January 2012, Lazio confirmed that Cana would miss six weeks due to a back injury sustained in training. Cana hit form following the return, winning a place in the starting lineup, also thanks to Lazio's players being haunted with injuries and suspensions. He netted the second of campaign on 6 May 2012, a 25-yard goal versus
Atalanta, to keep Lazio's
UEFA Champions League hopes alive. He concluded his first season in
Rome by making 15 league appearances as Lazio finished 4th in the championship. Cana begun utilised as
centre-back under manager
Vladimir Petković in the
2012–13 season. The move was praised by Italian media. On 23 February 2013, Cana made a great performance in the
2012–13 Europa League round of 16 2–0 win over
Borussia Mönchengladbach which earned him a place at
UEFA's best XI of the week. Cana spent the 2012–13 season between bench and playing field, collecting 38 appearances in all competitions, including 24 in league. He also made 5 cup appearances, including the
final as Lazio beat city rivals
Roma to win the trophy for the 6th time. This win constituted his first trophy win at Lazio. Cana was a regular starter during the first part of
2013–14 campaign. He netted his first goal of the season on 24 November 2013, a last-minute equalizer to save a 1–1 draw at
Sampdoria. It was his first goal after 18 months. However, Cana struggled to play in the second part under new manager
Edy Reja, as the Italian did not see him as a lineup player. Cana scored his second of the campaign later on 2 March 2014, an early goal via a bicycle kick, as Lazio won 1–0 at
Fiorentina. Cana finished his second Lazio season by playing 32 matches in all competitions. With 344 balls recovered in 16 matches, Cana was ranked fourth-best defender in Serie A. Cana struggled for minutes in the
2014–15 season due to rivality with newly signed defenders
Stefan de Vrij and
Santiago Gentiletti. Cana however played full-90 minutes in the opening match of
2014–15 Serie A versus
Milan, a 1–3 loss at
San Siro. He made his 100th Lazio appearance on 7 December by entering as a substitute in the 1–2 win over
Parma. He spent the majority of his 4th season in Italy on bench, recording only 20 appearances between league and cup. He left the club afterwards.
Nantes in 2015 After four years in Italy with Lazio, on 31 August 2015 Cana returned to Ligue 1 by signing a two-year contract with
Nantes. He made his competitive debut for Nantes in September and soon became one of the team's most experienced figures. During the
2015–16 Ligue 1 season, Cana made 21 league appearances, mostly playing the full 90 minutes, although he also spent several matches as an unused substitute.
Retirement After leaving Nantes in the summer of 2016, Cana remained without a club amid reports that he was suffering from heart-related health problems that prevented him from continuing to play at a professional level. In an interview with L'Équipe published in October 2017, he revealed that he had been diagnosed with myocarditis — an inflammation of the heart muscle — following a viral infection, and that medical specialists had advised him to end his career for health reasons. Cana stated that he had effectively stopped playing shortly after captaining Albania at UEFA Euro 2016, describing his condition as a key factor in the decision. ==International career==